ARRB2

CLASSIFICATION

Arrestin Beta ARRB2

NO. OF PROTEINS

21 (1 human)

ALIGNMENT

SEQUENCE

ns1           S1
M
G
E
K
P
G
T
R
V
F
10
      s1s2   S2
K
K
S
S
P
N
C
K
L
T
20
      s2s3 S3  
V
Y
L
G
K
R
D
F
V
D
30
s3s4       S4  
H
L
D
K
V
D
P
V
D
G
40
        s4s5    
V
V
L
V
D
P
D
Y
L
K
50
    S5            
D
R
K
V
F
V
T
L
T
C
60
        s5s6    
A
F
R
Y
G
R
E
D
L
D
70
          S6      
V
L
G
L
S
F
R
K
D
L
80
                   
F
I
A
T
Y
Q
A
F
P
P
90
s6h1            
V
P
N
P
P
R
P
P
T
R
100
H1                
L
Q
D
R
L
L
R
K
L
G
110
h1s7 S7        
Q
H
A
H
P
F
F
F
T
I
120
s7s8       S8  
P
Q
N
L
P
C
S
V
T
L
130
s8s9            
Q
P
G
P
E
D
T
G
K
A
140
S9                
C
G
V
D
F
E
I
R
A
F
150
    s9s10      
C
A
K
S
L
E
E
K
S
H
160
      S10        
K
R
N
S
V
R
L
V
I
R
170
        s10s11
K
V
Q
F
A
P
E
K
P
G
180
        S11      
P
Q
P
S
A
E
T
T
R
H
190
s11s12   S12
F
L
M
S
D
R
S
L
H
L
200
        s12s13 S13
E
A
S
L
D
K
E
L
Y
Y
210
s13s14 S14
H
G
E
P
L
N
V
N
V
H
220
  s14s15  
V
T
N
N
S
T
K
T
V
K
230
S15              
K
I
K
V
S
V
R
Q
Y
A
240
    s15s16 S16
D
I
C
L
F
S
T
A
Q
Y
250
                 
K
C
P
V
A
Q
L
E
Q
D
260
s16s17 S17  
D
Q
V
S
P
S
S
T
F
C
270
                   
K
V
Y
T
I
T
P
L
L
S
280
s17s18        
D
N
R
E
K
R
G
L
A
L
290
                   
D
G
K
L
K
H
E
D
T
N
300
                   
L
A
S
S
T
I
V
K
E
G
310
              S18
A
N
K
E
V
L
G
I
L
V
320
                   
S
Y
R
V
K
V
K
L
V
V
330
s18s19 S19  
S
R
G
G
D
V
S
V
E
L
340
                   
P
F
V
L
M
H
P
K
P
H
350
s19s20        
D
H
I
P
L
P
R
P
Q
S
360
                   
A
A
P
E
T
D
V
P
V
D
370
                   
T
N
L
I
E
F
D
T
N
Y
380
          S20    
A
T
D
D
D
I
V
F
E
D
390
s20c            
F
A
R
L
R
L
K
G
M
K
400
                 
D
D
D
Y
D
D
Q
L
C

DIAGRAMS


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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
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MUTATIONS

STRUCTURES

No structures available