Release notes

July 28, 2022
June 23, 2022
April 30, 2022
  • Updated GPCR and G protein structures
  • Updated GPCR ligand and bioactivity data to ChEMBL v30
  • Updated GPCR homology and refined structure models
  • Minor bug and performance fixes
March 30, 2022
  • Release of the new Biased Signaling resource
    • Bias calculations according to the recently published Community Guidelines for GPCR Ligand Bias
    • In-depth browsing and plotting of biased signaling data for individual receptors on transducer family and subtype level
    • Visualisation of the trends in the signaling data via the statistics pages
    • Annotation of endogenous ligands via the Guide to Pharmacology for identifying physiology-biased ligands
    • Comparison of receptor-signaling profiles between any ligand with signaling data for a given receptor
  • Revamped ligand handling in GPCRdb
    • Improved ligand identification, processing, curation, integration, and crosslinking
    • Updated GPCR ligand and bioactivity data from ChEMBL
    • Updated ligand vendor data from PubChem
    • Linking ligands to external sources (Guide to Pharmacology, ChEMBL, PubChem, Drug Central, and DrugBank)
  • Updated GPCR and G protein structures
  • Updated GPCR homology and refined structure models
  • Minor bug and performance fixes
Jan. 31, 2022
  • Updated GPCR and G protein structures
  • Updated GPCR-G protein complex structure models
  • Updated GPCR homology and refined structure models
  • Minor bug and performance fixes
Dec. 23, 2021
  • Updated GPCR and G protein structures
  • Minor bug and performance fixes
Nov. 4, 2021
Oct. 7, 2021
Sept. 10, 2021
July 20, 2021
June 14, 2021
May 14, 2021
April 14, 2021
March 18, 2021
  • Improved tree visualizations on all statistics pages
  • Updated GPCR and G protein structures
  • Updated GPCR homology and refined structure models
  • Added community-contributed mutation data
  • Updated references
  • Minor bug and performance fixes
Feb. 11, 2021
  • Improved structure download and superpositioning workflow
  • Updated GPCR structures
  • Updated GPCR homology and refined structure models
  • Minor bug and performance fixes
Jan. 12, 2021
Dec. 7, 2020
Nov. 4, 2020
Oct. 8, 2020
Sept. 3, 2020
  • Updated GPCR annotated structures and it's encompassing browser and accordingly updated statistics
  • Updated GPCR homology and refined structure models
  • Updated GPCR-G protein complex structure models
  • Updated ligand database
  • New and faster phylogenetic tree tool
  • New easy citation tool
  • New join us tool
  • Updated menu layout
Oct. 25, 2019 Recent additions (not reported here earlier)
March 11, 2019
Jan. 21, 2019
April 5, 2018
Nov. 15, 2017
July 25, 2017
May 17, 2017
Sept. 21, 2016
May 18, 2016
  • New Mutation Design Tool
  • More mutant data
  • Updated alignments for all proteins
  • Homology models (Class A)
  • B2-adrenoceptor - Gs protein interface
  • G protein assocation statistics
  • Import/export of receptor selections
  • Import/export of segment selections
Sept. 30, 2015
  • Re-designed interface
  • NC-IUPHAR nomenclature
  • Updated alignments for all proteins
  • New web services
  • Site search from PDB files
  • Improved mutant browser
  • More mutant data
  • Ligand interaction diagrams
  • BLAST search