Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
5ht5a_human 6 N-term N => S 2.688↓ pK(d) (Binding - Radioligand saturation) 5-hydroxytryptamine Dutton AC et al (2008) Vass M et al (2019)
5ht5a_human 21 N-term N => S 1.949↓ pK(d) (Binding - Radioligand saturation) 5-hydroxytryptamine Dutton AC et al (2008) Vass M et al (2019)
5ht5a_human 3.32x32 121 TM3 D => A Abolished pEC50 (Functional - Other) 5-CT Tan Y et al (2022)
5ht5a_human 3.33x33 122 TM3 V => A 200.0↓ pEC50 (Functional - Other) 5-CT Tan Y et al (2022)
5ht5a_human 3.36x36 125 TM3 C => A 50.0↓ pEC50 (Functional - Other) 5-CT Tan Y et al (2022)
5ht5a_human 45.52x52 194 ECL2 V => A 6.329↓ pEC50 (Functional - Other) 5-CT Tan Y et al (2022)
5ht5a_human 5.42x43 204 TM5 S => A 15.873↓ pEC50 (Functional - Other) 5-CT Tan Y et al (2022)
5ht5a_human 5.43x44 205 TM5 T => A 31.25↓ pEC50 (Functional - Other) 5-CT Tan Y et al (2022)
5ht5a_human 6.48x48 298 TM6 W => A 1.996↓ pEC50 (Functional - Other) 5-CT Tan Y et al (2022)
5ht5a_human 6.51x51 301 TM6 F => A 12.658↓ pEC50 (Functional - Other) 5-CT Tan Y et al (2022)
5ht5a_human 6.52x52 302 TM6 F => A 1.585↓ pEC50 (Functional - Other) 5-CT Tan Y et al (2022)
5ht5a_human 6.55x55 305 TM6 E => A 3.162↑ pEC50 (Functional - Other) 5-CT Tan Y et al (2022)
5ht5a_human 7.39x38 324 TM7 L => A 1.996↓ pEC50 (Functional - Other) 5-CT Tan Y et al (2022)
5ht5a_human 7.43x42 328 TM7 Y => A 500.0↓ pEC50 (Functional - Other) 5-CT Tan Y et al (2022)
5ht5a_human 6.55x55 305 TM6 E => A 3.162↑ pEC50 (Functional - Other) 5-CT Tan Y et al (2022)
5ht5a_human 6.55x55 305 TM6 E => S 1.995↑ pEC50 (Functional - Other) 5-CT Tan Y et al (2022)
5ht5a_human 5.42x43 204 TM5 S => A 5.012↑ pEC50 (Functional - Other) 5-hydroxytryptamine Zhang S et al (2022)
5ht5a_human 6.55x55 305 TM6 E => A 1.259↓ pEC50 (Functional - Other) 5-hydroxytryptamine Zhang S et al (2022)
5ht5a_human 45.52x52 194 ECL2 V => A 12.658↓ pEC50 (Functional - Other) 5-hydroxytryptamine Zhang S et al (2022)
5ht5a_human 3.33x33 122 TM3 V => A Abolished pEC50 (Functional - Other) 5-hydroxytryptamine Zhang S et al (2022)
5ht5a_human 3.36x36 125 TM3 C => A 76.923↓ pEC50 (Functional - Other) 5-hydroxytryptamine Zhang S et al (2022)
5ht5a_human 3.32x32 121 TM3 D => A Abolished pEC50 (Functional - Other) 5-hydroxytryptamine Zhang S et al (2022)
5ht5a_human 7.43x42 328 TM7 Y => A Abolished pEC50 (Functional - Other) 5-hydroxytryptamine Zhang S et al (2022)
5ht5a_human 6.48x48 298 TM6 W => A Abolished pEC50 (Functional - Other) 5-hydroxytryptamine Zhang S et al (2022)
5ht5a_human 3.37x37 126 TM3 T => A Abolished pEC50 (Functional - Other) 5-hydroxytryptamine Zhang S et al (2022)
5ht5a_human 6.51x51 301 TM6 F => A Abolished pEC50 (Functional - Other) 5-hydroxytryptamine Zhang S et al (2022)
5ht5a_human 5.46x461 208 TM5 A => G 40.0↓ pEC50 (Functional - Other) 5-hydroxytryptamine Zhang S et al (2022)
5ht5a_human 6.52x52 302 TM6 F => A 3.165↓ pEC50 (Functional - Other) 5-hydroxytryptamine Zhang S et al (2022)
5ht5a_human 3.29x29 118 TM3 I => A 3.984↓ pEC50 (Functional - Other) 5-hydroxytryptamine Zhang S et al (2022)
5ht5a_human 3.28x28 117 TM3 W => A 50.0↓ pEC50 (Functional - Other) 5-hydroxytryptamine Zhang S et al (2022)
5ht5a_human 7.39x38 324 TM7 L => A 1.996↓ pEC50 (Functional - Other) 5-hydroxytryptamine Zhang S et al (2022)
5ht5a_human 5.42x43 204 TM5 S => A 10.0↓ pEC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 6.55x55 305 TM6 E => A 2.512↑ pEC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 45.52x52 194 ECL2 V => A 12.658↓ pEC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 3.33x33 122 TM3 V => A Abolished pEC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 3.36x36 125 TM3 C => A 76.923↓ pEC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 3.32x32 121 TM3 D => A Abolished pEC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 7.43x42 328 TM7 Y => A Abolished pEC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 6.48x48 298 TM6 W => A Abolished pEC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 3.37x37 126 TM3 T => A Abolished pEC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 6.51x51 301 TM6 F => A Abolished pEC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 5.46x461 208 TM5 A => G 12.658↓ pEC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 6.52x52 302 TM6 F => A 1.585↓ pEC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 3.29x29 118 TM3 I => A 3.165↓ pEC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 3.28x28 117 TM3 W => A 62.5↓ pEC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 7.39x38 324 TM7 L => A 1.585↓ pEC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 5.42x43 204 TM5 S => A 2.512↑ pEC50 (Functional - Other) lisuride Zhang S et al (2022)
5ht5a_human 6.55x55 305 TM6 E => A 1.259↓ pEC50 (Functional - Other) lisuride Zhang S et al (2022)
5ht5a_human 45.52x52 194 ECL2 V => A 1.259↑ pEC50 (Functional - Other) lisuride Zhang S et al (2022)
5ht5a_human 3.33x33 122 TM3 V => A 1.259↓ pEC50 (Functional - Other) lisuride Zhang S et al (2022)
5ht5a_human 3.36x36 125 TM3 C => A Abolished pEC50 (Functional - Other) lisuride Zhang S et al (2022)
5ht5a_human 3.32x32 121 TM3 D => A Abolished pEC50 (Functional - Other) lisuride Zhang S et al (2022)
5ht5a_human 7.43x42 328 TM7 Y => A Abolished pEC50 (Functional - Other) lisuride Zhang S et al (2022)
5ht5a_human 6.48x48 298 TM6 W => A Abolished pEC50 (Functional - Other) lisuride Zhang S et al (2022)
5ht5a_human 3.37x37 126 TM3 T => A Abolished pEC50 (Functional - Other) lisuride Zhang S et al (2022)
5ht5a_human 6.51x51 301 TM6 F => A 3.162↑ pEC50 (Functional - Other) lisuride Zhang S et al (2022)
5ht5a_human 5.46x461 208 TM5 A => G 1.585↓ pEC50 (Functional - Other) lisuride Zhang S et al (2022)
5ht5a_human 6.52x52 302 TM6 F => A 1.259↓ pEC50 (Functional - Other) lisuride Zhang S et al (2022)
5ht5a_human 3.29x29 118 TM3 I => A 1.585↑ pEC50 (Functional - Other) lisuride Zhang S et al (2022)
5ht5a_human 3.28x28 117 TM3 W => A Abolished pEC50 (Functional - Other) lisuride Zhang S et al (2022)
5ht5a_human 7.39x38 324 TM7 L => A 1.259↓ pEC50 (Functional - Other) lisuride Zhang S et al (2022)
5ht5a_human 5.42x43 204 TM5 S => A 1.259↑ pEC50 (Functional - Other) methylergonovine Zhang S et al (2022)
5ht5a_human 6.55x55 305 TM6 E => A 1.0 pEC50 (Functional - Other) methylergonovine Zhang S et al (2022)
5ht5a_human 45.52x52 194 ECL2 V => A 2.513↓ pEC50 (Functional - Other) methylergonovine Zhang S et al (2022)
5ht5a_human 3.33x33 122 TM3 V => A 50.0↓ pEC50 (Functional - Other) methylergonovine Zhang S et al (2022)
5ht5a_human 3.36x36 125 TM3 C => A Abolished pEC50 (Functional - Other) methylergonovine Zhang S et al (2022)
5ht5a_human 3.32x32 121 TM3 D => A Abolished pEC50 (Functional - Other) methylergonovine Zhang S et al (2022)
5ht5a_human 7.43x42 328 TM7 Y => A Abolished pEC50 (Functional - Other) methylergonovine Zhang S et al (2022)
5ht5a_human 6.48x48 298 TM6 W => A Abolished pEC50 (Functional - Other) methylergonovine Zhang S et al (2022)
5ht5a_human 3.37x37 126 TM3 T => A Abolished pEC50 (Functional - Other) methylergonovine Zhang S et al (2022)
5ht5a_human 6.51x51 301 TM6 F => A Abolished pEC50 (Functional - Other) methylergonovine Zhang S et al (2022)
5ht5a_human 5.46x461 208 TM5 A => G 3.165↓ pEC50 (Functional - Other) methylergonovine Zhang S et al (2022)
5ht5a_human 6.52x52 302 TM6 F => A 3.165↓ pEC50 (Functional - Other) methylergonovine Zhang S et al (2022)
5ht5a_human 3.29x29 118 TM3 I => A 3.165↓ pEC50 (Functional - Other) methylergonovine Zhang S et al (2022)
5ht5a_human 3.28x28 117 TM3 W => A 1.585↓ pEC50 (Functional - Other) methylergonovine Zhang S et al (2022)
5ht5a_human 7.39x38 324 TM7 L => A 1.0 pEC50 (Functional - Other) methylergonovine Zhang S et al (2022)
5ht5a_human 5.42x43 204 TM5 S => A 4.182↑ EC50 (Functional - Other) 5-hydroxytryptamine Zhang S et al (2022)
5ht5a_human 5.42x43 204 TM5 S => G 1.211↑ EC50 (Functional - Other) 5-hydroxytryptamine Zhang S et al (2022)
5ht5a_human 5.42x43 204 TM5 S => C 34.483↓ EC50 (Functional - Other) 5-hydroxytryptamine Zhang S et al (2022)
5ht5a_human 5.42x43 204 TM5 S => A 13.514↓ EC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 5.42x43 204 TM5 S => G 43.478↓ EC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 5.42x43 204 TM5 S => C 1000.0↓ EC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 6.34x34 284 TM6 A => R 5.389↑ EC50 (Functional - Other) 5-hydroxytryptamine Zhang S et al (2022)
5ht5a_human 5.64x64 226 TM5 A => V 3.345↑ EC50 (Functional - Other) 5-hydroxytryptamine Zhang S et al (2022)
5ht5a_human 5.65x65 227 TM5 A => L 1.091↓ EC50 (Functional - Other) 5-hydroxytryptamine Zhang S et al (2022)
5ht5a_human 6.34x34 284 TM6 A => R 1.15↑ EC50 (Functional - Other) lisuride Zhang S et al (2022)
5ht5a_human 5.64x64 226 TM5 A => V 1.044↓ EC50 (Functional - Other) lisuride Zhang S et al (2022)
5ht5a_human 5.65x65 227 TM5 A => L 1.337↓ EC50 (Functional - Other) lisuride Zhang S et al (2022)
5ht5a_human 34.51x51 147 ICL2 M => A 1.538↓ EC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 5.68x68 230 TM5 R => A 1.961↓ EC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 3.54x54 143 TM3 I => A 1.192↓ EC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 3.53x53 142 TM3 S => A 1.499↓ EC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 8.47x47 342 H8 N => A 4.149↓ EC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 3.50x50 139 TM3 R => A Abolished EC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 4.38x38 154 TM4 R => A Abolished EC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 6.36x36 286 TM6 M => A 1.238↑ EC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 6.32x32 282 TM6 R => A 2.618↓ EC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 6.37x37 287 TM6 V => A Abolished EC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 5.61x61 223 TM5 I => A 3.195↓ EC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 34.50x50 146 ICL2 H => A 1.083↑ EC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 34.50x50 146 ICL2 H => P 1.345↑ EC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 34.51x51 147 ICL2 M => A 1.052↓ EC50 (Functional - Other) 5-CT Zhang S et al (2022)
5ht5a_human 2.65x64 101 TM2 E => D 1.259↑ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 2.65x64 101 TM2 E => Q 6.329↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 2.65x64 101 TM2 E => A 5.0↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 2.65x64 101 TM2 E => 1 6.329↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 3.32x32 121 TM3 D => A Abolished pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 3.33x33 122 TM3 V => A 100.0↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 3.36x36 125 TM3 C => A 10.0↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 3.36x36 125 TM3 C => S 7.937↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 45.51x51 193 ECL2 Q => A 3.165↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 45.51x51 193 ECL2 Q => L 2.513↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 45.51x51 193 ECL2 Q => 1 3.165↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 45.52x52 194 ECL2 V => L 7.937↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 45.52x52 194 ECL2 V => A 1.259↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 196 ECL2 R => A 3.165↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 5.39x40 201 TM5 A => T 3.165↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 5.39x40 201 TM5 A => F 3.165↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 5.42x43 204 TM5 S => A 1.585↑ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 5.42x43 204 TM5 S => G 5.0↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 5.43x44 205 TM5 T => A 6.329↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 5.46x461 208 TM5 A => G 7.937↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 6.51x51 301 TM6 F => A Abolished pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 6.52x52 302 TM6 F => A 1.585↑ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 6.55x55 305 TM6 E => A 1.585↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 7.39x38 324 TM7 L => A 62.5↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 7.39x38 324 TM7 L => T 62.5↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 7.39x38 324 TM7 L => N 62.5↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 7.43x42 328 TM7 Y => A Abolished pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 7.43x42 328 TM7 Y => F 12.658↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 5.38x39 200 TM5 Y => A 7.937↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 6.55x55 305 TM6 E => S 7.937↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 2.65x64 101 TM2 E => T 12.658↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL3654198 Zhang S et al (2022)
5ht5a_human 2.65x64 101 TM2 E => D 1.202↓ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 2.65x64 101 TM2 E => Q 1.412↓ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 2.65x64 101 TM2 E => A 1.621↓ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 2.65x64 101 TM2 E => 1 3.891↓ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 3.32x32 121 TM3 D => A Abolished pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 3.33x33 122 TM3 V => A 2.882↓ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 3.36x36 125 TM3 C => A 10.204↓ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 3.36x36 125 TM3 C => S 5.0↓ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 45.51x51 193 ECL2 Q => A 1.779↓ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 45.51x51 193 ECL2 Q => L 1.202↓ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 45.51x51 193 ECL2 Q => 1 1.658↓ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 45.52x52 194 ECL2 V => L 5.618↓ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 45.52x52 194 ECL2 V => A 2.755↓ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 196 ECL2 R => A 1.148↑ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 5.39x40 201 TM5 A => T 1.289↓ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 5.39x40 201 TM5 A => F 1.381↓ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 5.42x43 204 TM5 S => A 1.479↑ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 5.42x43 204 TM5 S => G 1.862↓ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 5.43x44 205 TM5 T => A 2.137↓ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 5.46x461 208 TM5 A => G 3.086↓ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 6.51x51 301 TM6 F => A Abolished pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 6.52x52 302 TM6 F => A 1.445↓ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 6.55x55 305 TM6 E => A 6.31↑ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 7.39x38 324 TM7 L => A 2.817↓ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 7.39x38 324 TM7 L => T 3.236↓ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 7.39x38 324 TM7 L => N 1.949↓ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 7.43x42 328 TM7 Y => A Abolished pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 7.43x42 328 TM7 Y => F 2.817↓ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 5.38x39 200 TM5 Y => A 5.0↓ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 6.55x55 305 TM6 E => S 2.817↓ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
5ht5a_human 2.65x64 101 TM2 E => T 1.779↓ pK(d) (Binding - Radioligand competition/displacement) Lysergide Zhang S et al (2022)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 R T F H ICL1ECL1 R R W Q L ECL1ICL2 H M E Y T ICL2ECL2 W G E T Y S E G S E E C Q V S R ECL2ICL3 V S P I S E A V E V K D S A K Q P Q M V F T V R H A T V T F Q P E G D ICL3ECL3 S C D I ECL3N-term M D L P V N L T S F S L S T P S P L E T N H S L G K D D L R P S S P L N-termC-term S R Q H C-term L S V F G V L I L T L L G F L V A A T F A W N L L V L A T I L R V R V P H N L V A S M A V S D V L V A A L V M P L S L V H E L S G G R R L C Q L W I A C D V L C C T A S I W N V T A I A L D R Y W S I T R L R T R K C V S N V M I A L T W A L S A V I S L A P L L F G E P S Y A V F S T V G A F Y L P L C V V L F V Y W K I Y K A A K F R V G S R K T N S T W R E Q K E Q R A A L M V G I L I G V F V L C W I P F F L T E L I S P L C P A I W K S I F L W L G Y S N S F F N P L I Y T A F N K N F K N Y N S A F F
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
L N W A F T A A V L F G L L T L I L V G 1 A S M A V S D V L V A L A V M P L S L V H 2 A T V N W I S A T C C L V D C A I W L Q 3 S N V M I A L T W A L S A V I S L A P L 4 Y V F L V V C L P L Y F A G V T S F V A Y 5 G I L I G V F V L C W I P F F L T E L I 6 L P N F F S N S Y G L W L F I S K W I 7
Download: PNG | SVG




Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT5A receptor
TM2
2x64 2.65x64 E101
TM3
3x28 3.28x28 W117
3x29 3.29x29 I118
3x32 3.32x32 D121
3x33 3.33x33 V122
3x36 3.36x36 C125
3x37 3.37x37 T126
3x50 3.50x50 R139
3x53 3.53x53 S142
3x54 3.54x54 I143
TM4
4x38 4.38x38 R154
TM5
5x39 5.38x39 Y200
5x40 5.39x40 A201
5x43 5.42x43 S204
5x44 5.43x44 T205
5x461 5.46x461 A208
5x61 5.61x61 I223
5x64 5.64x64 A226
5x65 5.65x65 A227
5x68 5.68x68 R230
TM6
6x32 6.32x32 R282
6x34 6.34x34 A284
6x36 6.36x36 M286
6x37 6.37x37 V287
6x48 6.48x48 W298
6x51 6.51x51 F301
6x52 6.52x52 F302
6x55 6.55x55 E305
TM7
7x38 7.39x38 L324
7x42 7.43x42 Y328
H8
8x47 8.47x47 N342