Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
cckar_human 38 N-term E => D N/A N/A Kennedy K et al (1997)
cckar_human 1.30x30 39 TM1 W => F N/A N/A Kennedy K et al (1997)
cckar_human 1.31x31 40 TM1 Q => N N/A N/A Kennedy K et al (1997)
cckar_human 1.33x33 42 TM1 A => V N/A N/A Kennedy K et al (1997)
cckar_human 1.30x30 39 TM1 W => I N/A N/A Kennedy K et al (1997)
cckar_human 1.31x31 40 TM1 Q => E N/A N/A Kennedy K et al (1997)
cckar_human 2 N-term D => F N/A N/A Archer-Lahlou E et al (2005)
cckar_human 38 N-term E => D N/A N/A Kennedy K et al (1997)
cckar_human 1.30x30 39 TM1 W => F N/A N/A Kennedy K et al (1997)
cckar_human 1.30x30 39 TM1 W => F N/A N/A Archer-Lahlou E et al (2005)
cckar_human 1.30x30 39 TM1 W => I N/A N/A Kennedy K et al (1997)
cckar_human 1.31x31 40 TM1 Q => E N/A N/A Kennedy K et al (1997)
cckar_human 1.31x31 40 TM1 Q => N N/A N/A Kennedy K et al (1997)
cckar_human 1.31x31 40 TM1 Q => N N/A N/A Archer-Lahlou E et al (2005)
cckar_human 1.33x33 42 TM1 A => V N/A N/A Kennedy K et al (1997)
cckar_human 1.41x41 50 TM1 L => A N/A N/A Escrieut C et al (2002)
cckar_human 1.41x41 50 TM1 L => M N/A N/A Archer-Lahlou E et al (2005)
cckar_human 1.42x42 51 TM1 I => A N/A N/A Escrieut C et al (2002)
cckar_human 1.42x42 51 TM1 I => M N/A N/A Archer-Lahlou E et al (2005)
cckar_human 1.44x44 53 TM1 L => A N/A N/A Escrieut C et al (2002)
cckar_human 1.44x44 53 TM1 L => M N/A N/A Archer-Lahlou E et al (2005)
cckar_human 1.59x59 68 TM1 R => L N/A N/A Wu SV et al (1999)
cckar_human 1.60x60 69 TM1 N => S N/A N/A Wu SV et al (1999)
cckar_human 12.50x50 72 ICL1 M => L N/A N/A Wu SV et al (1999)
cckar_human 2.50x50 87 TM2 D => A N/A N/A Archer-Lahlou E et al (2005)
cckar_human 2.50x50 87 TM2 D => E N/A N/A Archer-Lahlou E et al (2005)
cckar_human 2.57x56 94 TM2 C => L N/A N/A Escrieut C et al (2002)
cckar_human 2.57x56 94 TM2 C => M N/A N/A Archer-Lahlou E et al (2005)
cckar_human 2.68x67 105 TM2 K => L N/A N/A Archer-Lahlou E et al (2005)
cckar_human 23.49x49 106 ECL1 D => A N/A N/A Archer-Lahlou E et al (2005)
cckar_human 23.50x50 107 ECL1 F => A N/A N/A Martin-Martinez M et al (2005)
cckar_human 23.50x50 107 ECL1 F => W N/A N/A Archer-Lahlou E et al (2005)
cckar_human 23.52x52 109 ECL1 F => W N/A N/A Archer-Lahlou E et al (2005)
cckar_human 3.26x26 115 TM3 K => A N/A N/A Gouldson P et al (1999)
cckar_human 3.26x26 115 TM3 K => A N/A N/A Archer-Lahlou E et al (2005)
cckar_human 3.26x26 115 TM3 K => L N/A N/A Archer-Lahlou E et al (2005)
cckar_human 3.28x28 117 TM3 T => A N/A N/A Archer-Lahlou E et al (2005)
cckar_human 3.28x28 117 TM3 T => A N/A N/A Martin-Martinez M et al (2005)
cckar_human 3.29x29 118 TM3 T => A N/A N/A Archer-Lahlou E et al (2005)
cckar_human 3.32x32 121 TM3 M => A N/A N/A Escrieut C et al (2002)
cckar_human 3.32x32 121 TM3 M => V N/A N/A Escrieut C et al (2002)
cckar_human 3.32x32 121 TM3 M => V N/A N/A Archer-Lahlou E et al (2005)
cckar_human 3.35x35 124 TM3 S => A N/A N/A Archer-Lahlou E et al (2005)
cckar_human 3.36x36 125 TM3 V => A N/A N/A Escrieut C et al (2002)
cckar_human 3.36x36 125 TM3 V => F N/A N/A Archer-Lahlou E et al (2005)
cckar_human 3.50x50 139 TM3 R => E N/A N/A Archer-Lahlou E et al (2005)
cckar_human 4.54x54 170 TM4 F => A N/A N/A Archer-Lahlou E et al (2005)
cckar_human 187 ECL2 K => A N/A N/A Gouldson P et al (1999)
cckar_human 187 ECL2 K => A N/A N/A Archer-Lahlou E et al (2005)
cckar_human 195 ECL2 M => L N/A N/A Martin-Martinez M et al (2005)
cckar_human 195 ECL2 M => Y N/A N/A Archer-Lahlou E et al (2005)
cckar_human 195 ECL2 M => Y N/A N/A Martin-Martinez M et al (2005)
cckar_human 45.51x51 197 ECL2 R => M N/A N/A Gigoux V et al (1999)
cckar_human 45.51x51 197 ECL2 R => M N/A N/A Escrieut C et al (2002)
cckar_human 45.51x51 197 ECL2 R => M N/A N/A Martin-Martinez M et al (2005)
cckar_human 45.51x51 197 ECL2 R => Y N/A N/A Escrieut C et al (2002)
cckar_human 45.51x51 197 ECL2 R => Y N/A N/A Archer-Lahlou E et al (2005)
cckar_human 45.51x51 197 ECL2 R => Y N/A N/A Martin-Martinez M et al (2005)
cckar_human 5.47x47 218 TM5 F => A N/A N/A Escrieut C et al (2002)
cckar_human 5.47x47 218 TM5 F => A N/A N/A Archer-Lahlou E et al (2005)
cckar_human 6.30x30 308 TM6 K => M N/A N/A Archer-Lahlou E et al (2005)
cckar_human 6.31x31 309 TM6 K => T N/A N/A Archer-Lahlou E et al (2005)
cckar_human 6.48x48 326 TM6 W => A N/A N/A Escrieut C et al (2002)
cckar_human 6.48x48 326 TM6 W => F N/A N/A Archer-Lahlou E et al (2005)
cckar_human 6.51x51 329 TM6 I => A N/A N/A Escrieut C et al (2002)
cckar_human 6.51x51 329 TM6 I => A N/A N/A Martin-Martinez M et al (2005)
cckar_human 6.51x51 329 TM6 I => F N/A N/A Escrieut C et al (2002)
cckar_human 6.51x51 329 TM6 I => F N/A N/A Archer-Lahlou E et al (2005)
cckar_human 6.51x51 329 TM6 I => F N/A N/A Martin-Martinez M et al (2005)
cckar_human 6.52x52 330 TM6 F => A N/A N/A Escrieut C et al (2002)
cckar_human 6.52x52 330 TM6 F => A N/A N/A Archer-Lahlou E et al (2005)
cckar_human 6.55x55 333 TM6 N => A N/A N/A Gigoux V et al (1999)
cckar_human 6.55x55 333 TM6 N => A N/A N/A Escrieut C et al (2002)
cckar_human 6.55x55 333 TM6 N => A N/A N/A Archer-Lahlou E et al (2005)
cckar_human 6.55x55 333 TM6 N => A N/A N/A Martin-Martinez M et al (2005)
cckar_human 6.55x55 333 TM6 N => Y N/A N/A Martin-Martinez M et al (2005)
cckar_human 6.58x58 336 TM6 R => A N/A N/A Gigoux V et al (1999)
cckar_human 6.58x58 336 TM6 R => D N/A N/A Gigoux V et al (1999)
cckar_human 6.58x58 336 TM6 R => M N/A N/A Gigoux V et al (1999)
cckar_human 6.58x58 336 TM6 R => M N/A N/A Escrieut C et al (2002)
cckar_human 6.58x58 336 TM6 R => M N/A N/A Archer-Lahlou E et al (2005)
cckar_human 6.58x58 336 TM6 R => M N/A N/A Martin-Martinez M et al (2005)
cckar_human 6.58x58 336 TM6 R => Y N/A N/A Martin-Martinez M et al (2005)
cckar_human 342 ECL3 S => A N/A N/A Archer-Lahlou E et al (2005)
cckar_human 342 ECL3 S => A N/A N/A Martin-Martinez M et al (2005)
cckar_human 342 ECL3 S => W N/A N/A Martin-Martinez M et al (2005)
cckar_human 348 ECL3 S => A N/A N/A Martin-Martinez M et al (2005)
cckar_human 348 ECL3 S => M N/A N/A Archer-Lahlou E et al (2005)
cckar_human 7.35x34 352 TM7 I => A N/A N/A Escrieut C et al (2002)
cckar_human 7.35x34 352 TM7 I => A N/A N/A Martin-Martinez M et al (2005)
cckar_human 7.35x34 352 TM7 I => M N/A N/A Archer-Lahlou E et al (2005)
cckar_human 7.39x38 356 TM7 L => A N/A N/A Gouldson P et al (1999)
cckar_human 7.39x38 356 TM7 L => A N/A N/A Escrieut C et al (2002)
cckar_human 7.39x38 356 TM7 L => H N/A N/A Gouldson P et al (1999)
cckar_human 7.39x38 356 TM7 L => M N/A N/A Archer-Lahlou E et al (2005)
cckar_human 7.39x38 356 TM7 L => N N/A N/A Gouldson P et al (1999)
cckar_human 7.43x42 360 TM7 Y => F N/A N/A Escrieut C et al (2002)
cckar_human 7.43x42 360 TM7 Y => M N/A N/A Archer-Lahlou E et al (2005)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 K R M R ICL1ECL1 D F I F ECL1ICL2 P L Q S R V W Q ICL2ECL2 N L V P F T K N N N Q T A N M C R F L L P ECL2ICL3 Q K K S A K E R K P S T T S S G K Y E D S D G C Y L Q K T R P P R K L E L R Q L S T G S S S R A N R I R S N S ICL3ECL3 T A S A E R R L S ECL3N-term M D V V D S L L V N G S N I T P P C E L G L E N E T L F C L D Q P R P S K E N-termC-term P G P P G A R G E V G E E E E G G T T G A S L S R F S Y S H M S A S V P P Q C-term W Q P A V Q I L L Y S L I F L L S V L G N T L V I T V L I R N T V T N I F L L S L A V S D L M L C L F C M P F N L I P N L L K G S A V C K T T T Y F M G T S V S V S T F N L V A I S L E R Y G A I C K T K S H A L K V I A A T W C L S F T I M T P Y P I Y S N D V M Q Q S W H T F L L L I L F L I P G I V M M V A Y G L I S L E L Y Q G I K F E A S S A A N L M A K K R V I R M L I V I V V L F F L C W M P I F S A N A W R A Y D G T P I S F I L L L S Y T S S C V N P I I Y C F M N K R F M A C P N F R L G T F P C
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
T N G L V S L L F I L S Y L L I Q V A P 1 L S L A V S D L M L C F L C M P F N L I P 2 A V L N F T S V S V S T G M F Y T T T K 3 A L K V I A A T W C L S F T I M T P Y 4 Y A V M M V I G P I L F L I L L L F T H W 5 I V I V V L F F L C W M P I F S A N A W 6 I P N V C S S T Y S L L L I F S I P T 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
CCK1 receptor
TM1
1x30 1.30x30 W39
1x31 1.31x31 Q40
1x33 1.33x33 A42
1x41 1.41x41 L50
1x42 1.42x42 I51
1x44 1.44x44 L53
1x59 1.59x59 R68
1x60 1.60x60 N69
TM2
2x50 2.50x50 D87
2x56 2.57x56 C94
2x67 2.68x67 K105
TM3
3x26 3.26x26 K115
3x28 3.28x28 T117
3x29 3.29x29 T118
3x32 3.32x32 M121
3x35 3.35x35 S124
3x36 3.36x36 V125
3x50 3.50x50 R139
TM4
4x54 4.54x54 F170
TM5
5x47 5.47x47 F218
TM6
6x30 6.30x30 K308
6x31 6.31x31 K309
6x48 6.48x48 W326
6x51 6.51x51 I329
6x52 6.52x52 F330
6x55 6.55x55 N333
6x58 6.58x58 R336
TM7
7x34 7.35x34 I352
7x38 7.39x38 L356
7x42 7.43x42 Y360