Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
cnr2_human 174 ECL2 C => S N/A N/A Shire D et al (1996)
cnr2_human 179 ECL2 C => S N/A N/A Shire D et al (1996)
cnr2_human 3.28x28 109 TM3 K => A N/A N/A Tao Q et al (1999)
cnr2_human 3.28x28 109 TM3 K => R N/A N/A Tao Q et al (1999)
cnr2_human 2.50x50 80 TM2 D => E N/A N/A Tao Q et al (1998)
cnr2_human 2.50x50 80 TM2 D => N N/A N/A Tao Q et al (1998)
cnr2_human 3.49x49 130 TM3 D => A N/A N/A Rhee MH et al (2000)
cnr2_human 3.50x50 131 TM3 R => A N/A N/A Rhee MH et al (2000)
cnr2_human 3.51x51 132 TM3 Y => A N/A N/A Rhee MH et al (2000)
cnr2_human 4.50x50 158 TM4 W => A N/A N/A Rhee MH et al (2000)
cnr2_human 4.50x50 158 TM4 W => F N/A N/A Rhee MH et al (2000)
cnr2_human 4.50x50 158 TM4 W => Y N/A N/A Rhee MH et al (2000)
cnr2_human 172 ECL2 W => A N/A N/A Rhee MH et al (2000)
cnr2_human 172 ECL2 W => F N/A N/A Rhee MH et al (2000)
cnr2_human 5.46x46 197 TM5 F => V N/A N/A Song ZH et al (1999)
cnr2_human 172 ECL2 W => L N/A N/A Rhee MH et al (2000)
cnr2_human 172 ECL2 W => Y N/A N/A Rhee MH et al (2000)
cnr2_human 2.50x50 80 TM2 D => E N/A N/A Tao Q et al (1998)
cnr2_human 2.50x50 80 TM2 D => N N/A N/A Tao Q et al (1998)
cnr2_human 3.28x28 109 TM3 K => A N/A N/A Tao Q et al (1999)
cnr2_human 3.28x28 109 TM3 K => A N/A N/A McAllister SD et al (2002)
cnr2_human 3.28x28 109 TM3 K => R N/A N/A Tao Q et al (1999)
cnr2_human 4.50x50 158 TM4 W => A N/A N/A Rhee MH et al (2000)
cnr2_human 4.50x50 158 TM4 W => F N/A N/A Rhee MH et al (2000)
cnr2_human 4.50x50 158 TM4 W => Y N/A N/A Rhee MH et al (2000)
cnr2_human 4.53x53 161 TM4 S => A N/A N/A Gouldson P et al (2000)
cnr2_human 4.56x56 164 TM4 V => I N/A N/A Gouldson P et al (2000)
cnr2_human 4.57x57 165 TM4 S => A N/A N/A Gouldson P et al (2000)
cnr2_human 174 ECL2 C => S N/A N/A Gouldson P et al (2000)
cnr2_human 174 ECL2 C => S N/A N/A Shire D et al (1996)
cnr2_human 175 ECL2 C => S N/A N/A Gouldson P et al (2000)
cnr2_human 177 ECL2 R => S N/A N/A Gouldson P et al (2000)
cnr2_human 179 ECL2 C => S N/A N/A Gouldson P et al (2000)
cnr2_human 179 ECL2 C => S N/A N/A Shire D et al (1996)
cnr2_human 5.42x42 193 TM5 S => G N/A N/A Gouldson P et al (2000)
cnr2_human 7.53x53 299 TM7 Y => A N/A N/A Feng W et al (2001)
cnr2_human 8.57x57 313 H8 C => A N/A N/A Xie XQ et al (2005)
cnr2_human 320 C-term C => A N/A N/A Feng W et al (2001)
cnr2_human 320 C-term C => A N/A N/A Xie XQ et al (2005)
cnr2_human 172 ECL2 W => Y N/A N/A Rhee MH et al (2000)
cnr2_human 172 ECL2 W => Y N/A N/A Rhee MH et al (2000)
cnr2_human 172 ECL2 W => Y N/A N/A Rhee MH et al (2000)
cnr2_human 172 ECL2 W => F N/A N/A Rhee MH et al (2000)
cnr2_human 172 ECL2 W => F N/A N/A Rhee MH et al (2000)
cnr2_human 172 ECL2 W => F N/A N/A Rhee MH et al (2000)
cnr2_human 172 ECL2 W => A N/A N/A Rhee MH et al (2000)
cnr2_human 172 ECL2 W => L N/A N/A Rhee MH et al (2000)
cnr2_human 4.50x50 158 TM4 W => A N/A N/A Rhee MH et al (2000)
cnr2_human 4.50x50 158 TM4 W => Y N/A N/A Rhee MH et al (2000)
cnr2_human 4.50x50 158 TM4 W => F N/A N/A Rhee MH et al (2000)
cnr2_human 4.50x50 158 TM4 W => F N/A N/A Rhee MH et al (2000)
cnr2_human 4.50x50 158 TM4 W => F N/A N/A Rhee MH et al (2000)
cnr2_human 6.30x30 240 TM6 D => N N/A N/A Latek D et al (2011)
cnr2_human 3.32x32 113 TM3 V => L 1.462↓ K(i) (Binding - Radioligand competition/displacement) CP55940 Alqarni M et al (2014)
cnr2_human 3.32x32 113 TM3 V => L 6.098↓ K(i) (Binding - Radioligand competition/displacement) SR144528 Alqarni M et al (2014)
cnr2_human 3.32x32 113 TM3 V => L 1.092↑ K(i) (Binding - Radioligand competition/displacement) XIE95-26 Alqarni M et al (2014)
cnr2_human 3.32x32 113 TM3 V => E Abolished K(i) (Binding - Radioligand competition/displacement) CP55940 Alqarni M et al (2014)
cnr2_human 3.32x32 113 TM3 V => E Abolished K(i) (Binding - Radioligand competition/displacement) SR144528 Alqarni M et al (2014)
cnr2_human 3.32x32 113 TM3 V => E Abolished K(i) (Binding - Radioligand competition/displacement) XIE95-26 Alqarni M et al (2014)
cnr2_human 5.41x41 192 TM5 L => A 1.13↑ K(i) (Binding - Radioligand competition/displacement) CP55940 Alqarni M et al (2014)
cnr2_human 5.41x41 192 TM5 L => A 4.808↓ K(i) (Binding - Radioligand competition/displacement) SR144528 Alqarni M et al (2014)
cnr2_human 5.41x41 192 TM5 L => A 25.246↑ K(i) (Binding - Radioligand competition/displacement) XIE95-26 Alqarni M et al (2014)
cnr2_human 5.41x41 192 TM5 L => S Abolished K(i) (Binding - Radioligand competition/displacement) CP55940 Alqarni M et al (2014)
cnr2_human 5.41x41 192 TM5 L => S Abolished K(i) (Binding - Radioligand competition/displacement) SR144528 Alqarni M et al (2014)
cnr2_human 5.41x41 192 TM5 L => S Abolished K(i) (Binding - Radioligand competition/displacement) XIE95-26 Alqarni M et al (2014)
cnr2_human 3.32x32 113 TM3 V => L 3.299↑ EC50 (Functional - cAMP accumulation) CP55940 Alqarni M et al (2014)
cnr2_human 5.41x41 192 TM5 L => A 228.571↑ EC50 (Functional - cAMP accumulation) CP55940 Alqarni M et al (2014)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 H Q L R R ICL1ECL1 F H G V D ECL1ICL2 P P S Y K A L L ICL2ECL2 W T C C P R P C S E L F P L I ECL2ICL3 H Q D R Q V P G M A R M ICL3ECL3 T L ECL3N-term M E E C W V T E I A N G S K D G L D S N P M K D Y M I L N-termC-term C V R G L G S E A K E E A P R S S V T E T E A D G K I T P W P D S R D L D L S D C C-term S G P Q K T A V A V L C T L L G L L S A L E N V A V L Y L I L S S K P S Y L F I G S L A G A D F L A S V V F A C S F V N F H V S K A V F L L K I G S V T M T F T A S V G S L L L T A I D R Y L C L R Y T R G R A L V T L G I M W V L S A L V S Y L P L M G P N D Y L L S W L L F I A F L F S G I I Y T Y G H V L W K A H Q H V A S L S G R L D V R L A K T L G L V L A V L L I C W F P V L A L M A H S L A T S D Q V K K A F A F C S M L C L I N S M V N P V I Y A L R S G E A H H W K K I R S S C L A H
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
V N E L A S L L G L L T C L V A V A T K 1 G S L A G A D F L A S V V F A C S F V N 2 L L L S G V S A T F T M T V S G I K L L 3 A L V T L G I M W V L S A L V S Y L P L 4 Y T Y I I G S F L F A I F L L W S L L Y 5 G L V L A V L L I C W F P V L A L M A H 6 V P N V M S N I L C L M S C F A F A K 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
CB2 receptor
TM2
2x50 2.50x50 D80
TM3
3x28 3.28x28 K109
3x32 3.32x32 V113
3x49 3.49x49 D130
3x50 3.50x50 R131
3x51 3.51x51 Y132
TM4
4x50 4.50x50 W158
4x53 4.53x53 S161
4x56 4.56x56 V164
4x57 4.57x57 S165
TM5
5x41 5.41x41 L192
5x42 5.42x42 S193
5x46 5.46x46 F197
TM6
6x30 6.30x30 D240
TM7
7x53 7.53x53 Y299
H8
8x57 8.57x57 C313