ArrestinDb

Mutant Browser

Protein name	Generic number	Position	Segment	Mutation	FoldChange or Qual	Exp Type	Ligand	Reference	Review

glp1r_human		32	N-term	L => A	7.092↓	IC50 (Binding - Radioligand competition/displacement)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		32	N-term	L => A	9.434↓	EC50 (Functional - cAMP accumulation)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		32	N-term	L => A	1.1↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Yang D et al (2016)
glp1r_human		32	N-term	L => A	1.091↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		35	N-term	T => A	1.727↑	IC50 (Binding - Radioligand competition/displacement)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		35	N-term	T => A	4.184↓	EC50 (Functional - cAMP accumulation)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		35	N-term	T => A	3.096↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Yang D et al (2016)
glp1r_human		35	N-term	T => A	2.725↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		36	N-term	V => A	1.289↓	IC50 (Binding - Radioligand competition/displacement)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		36	N-term	V => A	6.536↓	EC50 (Functional - cAMP accumulation)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		36	N-term	V => A	2.801↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Yang D et al (2016)
glp1r_human		36	N-term	V => A	5.181↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		68	N-term	E => A	1.583↑	IC50 (Binding - Radioligand competition/displacement)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		68	N-term	E => A	1.727↓	EC50 (Functional - cAMP accumulation)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		68	N-term	E => A	1.901↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Yang D et al (2016)
glp1r_human		68	N-term	E => A	1.364↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		69	N-term	Y => A	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		69	N-term	Y => A	Abolished effect	EC50 (Functional - cAMP accumulation)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		69	N-term	Y => A	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Yang D et al (2016)
glp1r_human		69	N-term	Y => A	Abolished effect	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		88	N-term	Y => A	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		88	N-term	Y => A	Abolished effect	EC50 (Functional - cAMP accumulation)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		88	N-term	Y => A	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Yang D et al (2016)
glp1r_human		88	N-term	Y => A	Abolished effect	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		89	N-term	L => A	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		89	N-term	L => A	Abolished effect	EC50 (Functional - cAMP accumulation)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		89	N-term	L => A	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Yang D et al (2016)
glp1r_human		89	N-term	L => A	Abolished effect	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		90	N-term	P => A	2.105↓	IC50 (Binding - Radioligand competition/displacement)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		90	N-term	P => A	5.464↓	EC50 (Functional - cAMP accumulation)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		90	N-term	P => A	2.801↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Yang D et al (2016)
glp1r_human		90	N-term	P => A	5.0↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		121	N-term	R => A	1.58↓	IC50 (Binding - Radioligand competition/displacement)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		121	N-term	R => A	8.0↓	EC50 (Functional - cAMP accumulation)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		121	N-term	R => A	2.299↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Yang D et al (2016)
glp1r_human		121	N-term	R => A	4.63↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		123	N-term	L => A	2.303↑	IC50 (Binding - Radioligand competition/displacement)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		123	N-term	L => A	1.727↓	EC50 (Functional - cAMP accumulation)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		123	N-term	L => A	1.1↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Yang D et al (2016)
glp1r_human		123	N-term	L => A	1.546↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		127	N-term	E => A	6.849↓	IC50 (Binding - Radioligand competition/displacement)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		127	N-term	E => Q	1.079↓	IC50 (Binding - Radioligand competition/displacement)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		127	N-term	E => A	2.0↓	EC50 (Functional - cAMP accumulation)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		127	N-term	E => Q	1.236↓	EC50 (Functional - cAMP accumulation)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		127	N-term	E => A	1.701↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Yang D et al (2016)
glp1r_human		127	N-term	E => Q	1.1↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Yang D et al (2016)
glp1r_human		127	N-term	E => A	1.182↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		127	N-term	E => Q	1.091↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		128	N-term	E => A	2.37↓	IC50 (Binding - Radioligand competition/displacement)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		128	N-term	E => Q	1.689↑	IC50 (Binding - Radioligand competition/displacement)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		128	N-term	E => A	4.545↓	EC50 (Functional - cAMP accumulation)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		128	N-term	E => Q	1.453↓	EC50 (Functional - cAMP accumulation)	Exendin-4	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		128	N-term	E => A	2.703↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Yang D et al (2016)
glp1r_human		128	N-term	E => Q	1.515↑	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Yang D et al (2016)
glp1r_human		128	N-term	E => A	2.545↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		128	N-term	E => Q	1.1↑	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Underwood CR et al (2010)	Graaf Cd et al (2016)
glp1r_human		63	N-term	N => L	1.035↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Chen Q et al (2010)	Graaf Cd et al (2016)
glp1r_human		63	N-term	N => L	2.421↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Chen Q et al (2010)	Graaf Cd et al (2016)
glp1r_human		82	N-term	N => L	1.647↑	IC50 (Binding - unknown pharmacological activity)	glucagon-like peptide 1-(7-37)	Chen Q et al (2010)	Graaf Cd et al (2016)
glp1r_human		82	N-term	N => L	2.347↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Chen Q et al (2010)	Graaf Cd et al (2016)
glp1r_human		115	N-term	N => L	1.0	IC50 (Binding - unknown pharmacological activity)	glucagon-like peptide 1-(7-37)	Chen Q et al (2010)	Graaf Cd et al (2016)
glp1r_human		115	N-term	N => L	2.155↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Chen Q et al (2010)	Graaf Cd et al (2016)
glp1r_human		68	N-term	E => K	1.969↓	EC50 (Functional - cAMP accumulation)	glucagon	Day JW et al (2011)	Graaf Cd et al (2016)
glp1r_human		68	N-term	E => K	1.773↓	EC50 (Functional - cAMP accumulation)	glucagon-(Ser22Glu)	Day JW et al (2011)	Graaf Cd et al (2016)
glp1r_human		68	N-term	E => K	4.292↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-35)	Day JW et al (2011)	Graaf Cd et al (2016)
glp1r_human		68	N-term	E => K	8.403↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Day JW et al (2011)	Graaf Cd et al (2016)
glp1r_human		68	N-term	E => K	4.484↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(Arg36Gly)	Day JW et al (2011)	Graaf Cd et al (2016)
glp1r_human		68	N-term	E => K	4.587↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(Gln22Glu)-(7-35)	Day JW et al (2011)	Graaf Cd et al (2016)
glp1r_human		68	N-term	E => K	10.638↓	EC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Day JW et al (2011)	Graaf Cd et al (2016)
glp1r_human		128	N-term	E => M	1.575↓	EC50 (Functional - cAMP accumulation)	glucagon	Day JW et al (2011)	Graaf Cd et al (2016)
glp1r_human		128	N-term	E => M	1.182↓	EC50 (Functional - cAMP accumulation)	glucagon-(Ser22Glu)	Day JW et al (2011)	Graaf Cd et al (2016)
glp1r_human		128	N-term	E => M	1.5↑	EC50 (Functional - cAMP accumulation)	glucagon-(Ser26Lys)	Day JW et al (2011)	Graaf Cd et al (2016)
glp1r_human		128	N-term	E => M	2.681↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Day JW et al (2011)	Graaf Cd et al (2016)
glp1r_human	1.47x47	152	TM1	Y => A	10.526↓	pK(d) (Binding - Radioligand saturation)	exendin-(9-39)	Coopman K et al (2011)	Graaf Cd et al (2016)
glp1r_human	1.47x47	152	TM1	Y => A	31.25↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Coopman K et al (2011)	Yang D et al (2016)
glp1r_human	1.47x47	152	TM1	Y => A	17.241↓	pEC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Coopman K et al (2011)	Graaf Cd et al (2016)
glp1r_human	1.47x47	152	TM1	Y => A	17.241↓	pEC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Coopman K et al (2011)	Graaf Cd et al (2016)
glp1r_human	2.60x60	190	TM2	R => A	6.173↓	pK(d) (Binding - Radioligand saturation)	exendin-(9-39)	Coopman K et al (2011)	Graaf Cd et al (2016)
glp1r_human	2.60x60	190	TM2	R => A	27.778↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Coopman K et al (2011)	Yang D et al (2016)
glp1r_human	2.60x60	190	TM2	R => A	166.667↓	pEC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Coopman K et al (2011)	Graaf Cd et al (2016)
glp1r_human	2.60x60	190	TM2	R => A	166.667↓	pEC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Coopman K et al (2011)	Graaf Cd et al (2016)
glp1r_human	2.67x67	197	TM2	K => A	3.021↓	pK(d) (Binding - Radioligand saturation)	exendin-(9-39)	Coopman K et al (2011)	Yang D et al (2016)
glp1r_human	2.67x67	197	TM2	K => A	22.727↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Coopman K et al (2011)	Yang D et al (2016)
glp1r_human	2.67x67	197	TM2	K => A	500.0↓	pEC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Coopman K et al (2011)	Graaf Cd et al (2016)
glp1r_human	2.67x67	197	TM2	K => A	500.0↓	pEC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Coopman K et al (2011)	Graaf Cd et al (2016)
glp1r_human	2.68x68	198	TM2	D => A	2.571↓	pK(d) (Binding - Radioligand saturation)	exendin-(9-39)	Coopman K et al (2011)	Graaf Cd et al (2016)
glp1r_human	2.68x68	198	TM2	D => A	1000.0↓	pEC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Coopman K et al (2011)	Graaf Cd et al (2016)
glp1r_human	2.68x68	198	TM2	D => A	43.478↓	pK(i) (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Coopman K et al (2011)	Yang D et al (2016)
glp1r_human	2.68x68	198	TM2	D => A	1000.0↓	pEC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Coopman K et al (2011)	Graaf Cd et al (2016)
glp1r_human	3.37x37	234	TM3	Q => A	3.311↓	pK(d) (Binding - Radioligand saturation)	exendin-(9-39)	Coopman K et al (2011)	Yang D et al (2016)
glp1r_human	3.37x37	234	TM3	Q => A	45.455↓	pEC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Coopman K et al (2011)	Graaf Cd et al (2016)
glp1r_human	3.37x37	234	TM3	Q => A	12.658↓	pK(i) (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Coopman K et al (2011)	Yang D et al (2016)
glp1r_human	3.37x37	234	TM3	Q => A	45.455↓	pEC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Coopman K et al (2011)	Graaf Cd et al (2016)
glp1r_human	3.38x38	235	TM3	Y => A	18.519↓	pK(d) (Binding - Radioligand saturation)	exendin-(9-39)	Coopman K et al (2011)	Yang D et al (2016)
glp1r_human	3.38x38	235	TM3	Y => A	21.739↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Coopman K et al (2011)	Graaf Cd et al (2016)
glp1r_human	3.38x38	235	TM3	Y => A	23.81↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Coopman K et al (2011)	Yang D et al (2016)
glp1r_human	3.38x38	235	TM3	Y => A	21.739↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Coopman K et al (2011)	Graaf Cd et al (2016)
glp1r_human	4.60x60	284	TM4	W => A	4.566↓	pK(d) (Binding - Radioligand saturation)	exendin-(9-39)	Coopman K et al (2011)	Yang D et al (2016)
glp1r_human	4.60x60	284	TM4	W => A	1000.0↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Coopman K et al (2011)	Graaf Cd et al (2016)
glp1r_human	4.60x60	284	TM4	W => A	28.571↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Coopman K et al (2011)	Yang D et al (2016)
glp1r_human	4.60x60	284	TM4	W => A	1000.0↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Coopman K et al (2011)	Graaf Cd et al (2016)
glp1r_human	5.40x40	310	TM5	R => A	2.188↓	pK(d) (Binding - Radioligand saturation)	exendin-(9-39)	Coopman K et al (2011)	Yang D et al (2016)
glp1r_human	5.40x40	310	TM5	R => A	10.0↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Coopman K et al (2011)	Yang D et al (2016)
glp1r_human	5.40x40	310	TM5	R => A	1000.0↓	pEC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Coopman K et al (2011)	Graaf Cd et al (2016)
glp1r_human	5.40x40	310	TM5	R => A	1000.0↓	pEC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Coopman K et al (2011)	Graaf Cd et al (2016)
glp1r_human	6.52x52	363	TM6	H => A	41.667↓	pK(d) (Binding - Radioligand saturation)	exendin-(9-39)	Coopman K et al (2011)	Yang D et al (2016)
glp1r_human	6.52x52	363	TM6	H => A	100.0↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Coopman K et al (2011)	Yang D et al (2016)
glp1r_human	6.52x52	363	TM6	H => A	Abolished effect	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Coopman K et al (2011)	Graaf Cd et al (2016)
glp1r_human	6.53x53	364	TM6	E => A	76.923↓	pK(d) (Binding - Radioligand saturation)	exendin-(9-39)	Coopman K et al (2011)	Yang D et al (2016)
glp1r_human	6.53x53	364	TM6	E => A	58.824↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Coopman K et al (2011)	Yang D et al (2016)
glp1r_human	6.53x53	364	TM6	E => A	14.706↓	pEC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Coopman K et al (2011)	Graaf Cd et al (2016)
glp1r_human	6.53x53	364	TM6	E => A	14.706↓	pEC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Coopman K et al (2011)	Graaf Cd et al (2016)
glp1r_human	7.42x41	387	TM7	E => A	3.891↓	pK(d) (Binding - Radioligand saturation)	exendin-(9-39)	Coopman K et al (2011)	Yang D et al (2016)
glp1r_human	7.42x41	387	TM7	E => A	1.35↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Coopman K et al (2011)	Yang D et al (2016)
glp1r_human	7.42x41	387	TM7	E => A	2.457↓	pEC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Coopman K et al (2011)	Graaf Cd et al (2016)
glp1r_human	7.42x41	387	TM7	E => A	2.457↓	pEC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Coopman K et al (2011)	Graaf Cd et al (2016)
glp1r_human	7.46x45	391	TM7	T => A	2.817↓	pK(d) (Binding - Radioligand saturation)	exendin-(9-39)	Coopman K et al (2011)	Yang D et al (2016)
glp1r_human	7.46x45	391	TM7	T => A	1.139↑	IC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Coopman K et al (2011)	Yang D et al (2016)
glp1r_human	7.46x45	391	TM7	T => A	1.122↑	pEC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Coopman K et al (2011)	Graaf Cd et al (2016)
glp1r_human	7.46x45	391	TM7	T => A	1.122↑	pEC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Coopman K et al (2011)	Graaf Cd et al (2016)
glp1r_human	7.52x52	397	TM7	M => L	1.567↓	K(i) (Binding - Radioligand saturation)	CHEMBL410972	Dong M et al (2012)	Graaf Cd et al (2016)
glp1r_human	7.52x52	397	TM7	M => L	1.42↓	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Dong M et al (2012)	Graaf Cd et al (2016)
glp1r_human	7.52x52	397	TM7	M => L	12.987↓	EC50 (Functional - cAMP accumulation)	NRTFD	Dong M et al (2012)	Graaf Cd et al (2016)
glp1r_human	2.62x62	192	TM2	L => S	1.105↓	EC50 (Functional - cAMP accumulation)	compound 3	Rye Underwood C et al (2011)	Graaf Cd et al (2016)
glp1r_human	2.62x62	192	TM2	L => S	1.101↑	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Rye Underwood C et al (2011)	Graaf Cd et al (2016)
glp1r_human	2.65x65	195	TM2	F => L	2.836↑	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Rye Underwood C et al (2011)	Graaf Cd et al (2016)
glp1r_human	2.65x65	195	TM2	F => L	1.1↑	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Rye Underwood C et al (2011)	Graaf Cd et al (2016)
glp1r_human	3.44x44	241	TM3	Y => A	2.212↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Rye Underwood C et al (2011)	Graaf Cd et al (2016)
glp1r_human	3.44x44	241	TM3	Y => A	1.553↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Rye Underwood C et al (2011)	Graaf Cd et al (2016)
glp1r_human	4.54x54	278	TM4	L => M	1.056↑	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Rye Underwood C et al (2011)	Graaf Cd et al (2016)
glp1r_human	4.54x54	278	TM4	L => M	1.232↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Rye Underwood C et al (2011)	Graaf Cd et al (2016)
glp1r_human	7.46x45	391	TM7	T => A	3.311↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Rye Underwood C et al (2011)	Graaf Cd et al (2016)
glp1r_human	7.46x45	391	TM7	T => A	1.233↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Rye Underwood C et al (2011)	Graaf Cd et al (2016)
glp1r_human	4.61x61	285	TM4	G => A	1.0	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.61x61	285	TM4	G => A	1.259↓	pEC50 (Functional - ERK activation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.61x61	285	TM4	G => A	2.512↑	pEC50 (Functional - cAMP accumulation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.61x61	285	TM4	G => A	1.259↑	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.61x61	285	TM4	G => A	2.512↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.61x61	285	TM4	G => A	1.995↑	pEC50 (Functional - ERK activation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.62x62	286	TM4	I => A	1.0	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.62x62	286	TM4	I => A	1.0	pEC50 (Functional - ERK activation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.62x62	286	TM4	I => A	1.995↑	pEC50 (Functional - cAMP accumulation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.62x62	286	TM4	I => A	1.0	pEC50 (Functional - ERK activation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.62x62	286	TM4	I => A	1.585↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.62x62	286	TM4	I => A	1.259↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.63x63	287	TM4	V => A	1.0	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.63x63	287	TM4	V => A	1.996↓	pEC50 (Functional - ERK activation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.63x63	287	TM4	V => A	1.259↓	pEC50 (Functional - cAMP accumulation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.63x63	287	TM4	V => A	1.585↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.63x63	287	TM4	V => A	1.585↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.63x63	287	TM4	V => A	3.984↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.64x64	288	TM4	K => A	1.995↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.64x64	288	TM4	K => A	3.984↓	pEC50 (Functional - ERK activation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.64x64	288	TM4	K => A	Abolished effect	pEC50 (Functional - cAMP accumulation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.64x64	288	TM4	K => A	125.0↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.64x64	288	TM4	K => A	12.658↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.64x64	288	TM4	K => A	Abolished effect	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.65x65	289	TM4	Y => A	1.259↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.65x65	289	TM4	Y => A	1.259↑	pEC50 (Functional - ERK activation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.65x65	289	TM4	Y => A	1.995↑	pEC50 (Functional - cAMP accumulation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.65x65	289	TM4	Y => A	2.513↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.65x65	289	TM4	Y => A	1.585↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.65x65	289	TM4	Y => A	1.259↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.66x66	290	TM4	L => A	1.259↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.66x66	290	TM4	L => A	1.585↓	pEC50 (Functional - ERK activation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.66x66	290	TM4	L => A	1.0	pEC50 (Functional - cAMP accumulation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.66x66	290	TM4	L => A	1.996↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.66x66	290	TM4	L => A	1.585↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.66x66	290	TM4	L => A	1.259↑	pEC50 (Functional - ERK activation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.67x67	291	TM4	Y => A	1.259↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.67x67	291	TM4	Y => A	1.996↓	pEC50 (Functional - ERK activation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.67x67	291	TM4	Y => A	1.259↓	pEC50 (Functional - cAMP accumulation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.67x67	291	TM4	Y => A	2.513↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.67x67	291	TM4	Y => A	1.0	pEC50 (Functional - ERK activation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.67x67	291	TM4	Y => A	2.513↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.68x68	292	TM4	E => A	1.0	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.68x68	292	TM4	E => A	3.165↓	pEC50 (Functional - ERK activation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.68x68	292	TM4	E => A	Abolished effect	pEC50 (Functional - cAMP accumulation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.68x68	292	TM4	E => A	100.0↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.68x68	292	TM4	E => A	125.0↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	4.68x68	292	TM4	E => A	3.984↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		293	ECL2	D => A	1.585↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		293	ECL2	D => A	1.0	pEC50 (Functional - ERK activation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		293	ECL2	D => A	3.165↓	pEC50 (Functional - cAMP accumulation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		293	ECL2	D => A	15.873↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		293	ECL2	D => A	25.0↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		293	ECL2	D => A	1.996↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		294	ECL2	E => A	1.585↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		294	ECL2	E => A	1.259↓	pEC50 (Functional - ERK activation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		294	ECL2	E => A	1.259↑	pEC50 (Functional - cAMP accumulation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		294	ECL2	E => A	25.0↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		294	ECL2	E => A	1.0	pEC50 (Functional - ERK activation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		294	ECL2	E => A	1.259↑	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		295	ECL2	G => A	1.0	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		295	ECL2	G => A	1.996↓	pEC50 (Functional - ERK activation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		295	ECL2	G => A	1.259↑	pEC50 (Functional - cAMP accumulation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		295	ECL2	G => A	1.0	pEC50 (Functional - ERK activation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		295	ECL2	G => A	1.0	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		295	ECL2	G => A	1.259↑	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	45.50x50	296	ECL2	C => A	1.259↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	45.50x50	296	ECL2	C => A	3.981↑	pEC50 (Functional - ERK activation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	45.50x50	296	ECL2	C => A	Abolished effect	pEC50 (Functional - cAMP accumulation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	45.50x50	296	ECL2	C => A	7.937↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	45.50x50	296	ECL2	C => A	12.658↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	45.50x50	296	ECL2	C => A	125.0↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	45.51x51	297	ECL2	W => A	1.585↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	45.51x51	297	ECL2	W => A	5.012↑	pEC50 (Functional - ERK activation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	45.51x51	297	ECL2	W => A	Abolished effect	pEC50 (Functional - cAMP accumulation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	45.51x51	297	ECL2	W => A	62.5↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	45.51x51	297	ECL2	W => A	3.165↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	45.51x51	297	ECL2	W => A	333.333↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	45.52x52	298	ECL2	T => A	2.512↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	45.52x52	298	ECL2	T => A	3.981↑	pEC50 (Functional - ERK activation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	45.52x52	298	ECL2	T => A	3.162↑	pEC50 (Functional - cAMP accumulation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	45.52x52	298	ECL2	T => A	1.585↑	pEC50 (Functional - ERK activation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	45.52x52	298	ECL2	T => A	2.512↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	45.52x52	298	ECL2	T => A	5.012↑	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		299	ECL2	R => A	1.996↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		299	ECL2	R => A	1.995↑	pEC50 (Functional - ERK activation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		299	ECL2	R => A	1.259↓	pEC50 (Functional - cAMP accumulation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		299	ECL2	R => A	1.996↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		299	ECL2	R => A	31.25↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		299	ECL2	R => A	25.0↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		300	ECL2	N => A	1.585↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		300	ECL2	N => A	Abolished effect	pEC50 (Functional - ERK activation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		300	ECL2	N => A	Abolished effect	pEC50 (Functional - cAMP accumulation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		300	ECL2	N => A	125.0↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		300	ECL2	N => A	1.585↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		300	ECL2	N => A	500.0↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		301	ECL2	S => A	2.512↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		301	ECL2	S => A	1.259↑	pEC50 (Functional - ERK activation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		301	ECL2	S => A	1.585↑	pEC50 (Functional - cAMP accumulation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		301	ECL2	S => A	1.0	pEC50 (Functional - ERK activation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		301	ECL2	S => A	1.0	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human		301	ECL2	S => A	1.259↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.32x33	302	TM5	N => A	1.995↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.32x33	302	TM5	N => A	1.585↓	pEC50 (Functional - ERK activation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.32x33	302	TM5	N => A	1.996↓	pEC50 (Functional - cAMP accumulation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.32x33	302	TM5	N => A	25.0↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.32x33	302	TM5	N => A	1.996↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.32x33	302	TM5	N => A	15.873↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.33x34	303	TM5	M => A	2.512↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.33x34	303	TM5	M => A	1.0	pEC50 (Functional - ERK activation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.33x34	303	TM5	M => A	1.0	pEC50 (Functional - cAMP accumulation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.33x34	303	TM5	M => A	3.984↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.33x34	303	TM5	M => A	1.0	pEC50 (Functional - ERK activation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.33x34	303	TM5	M => A	3.165↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.34x35	304	TM5	N => A	1.585↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.34x35	304	TM5	N => A	1.995↑	pEC50 (Functional - ERK activation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.34x35	304	TM5	N => A	1.259↑	pEC50 (Functional - cAMP accumulation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.34x35	304	TM5	N => A	1.996↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.34x35	304	TM5	N => A	1.259↑	pEC50 (Functional - ERK activation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.34x35	304	TM5	N => A	3.165↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.35x36	305	TM5	Y => A	1.0	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.35x36	305	TM5	Y => A	1.995↑	pEC50 (Functional - ERK activation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.35x36	305	TM5	Y => A	2.513↓	pEC50 (Functional - cAMP accumulation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.35x36	305	TM5	Y => A	40.0↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.35x36	305	TM5	Y => A	1.996↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.35x36	305	TM5	Y => A	76.923↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.36x37	306	TM5	W => A	1.585↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.36x37	306	TM5	W => A	Abolished effect	pEC50 (Functional - ERK activation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.36x37	306	TM5	W => A	Abolished effect	pEC50 (Functional - cAMP accumulation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.36x37	306	TM5	W => A	25.0↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.36x37	306	TM5	W => A	Abolished effect	pEC50 (Functional - ERK activation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.36x37	306	TM5	W => A	Abolished effect	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.37x38	307	TM5	L => A	1.995↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.37x38	307	TM5	L => A	1.585↑	pEC50 (Functional - ERK activation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.37x38	307	TM5	L => A	1.996↓	pEC50 (Functional - cAMP accumulation)	CHEMBL2158410	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.37x38	307	TM5	L => A	25.0↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.37x38	307	TM5	L => A	12.658↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	5.37x38	307	TM5	L => A	1.585↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Koole C et al (2012)	Yang D et al (2016)
glp1r_human	1.50x50	155	TM1	S => A	3.472↓	pK(i) (Binding - Radioligand competition/displacement)	Exendin-4	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	1.50x50	155	TM1	S => A	1.072↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	1.50x50	155	TM1	S => A	2.398↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	1.50x50	155	TM1	S => A	1.047↑	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	2.50x50	180	TM2	H => A	Abolished effect	pK(i) (Binding - Radioligand competition/displacement)	Exendin-4	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	2.50x50	180	TM2	H => A	Abolished effect	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	2.50x50	180	TM2	H => A	Abolished effect	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	2.50x50	180	TM2	H => A	Abolished effect	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	2.56x56	186	TM2	S => A	1.122↑	pK(i) (Binding - Radioligand competition/displacement)	Exendin-4	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	2.56x56	186	TM2	S => A	1.479↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	2.56x56	186	TM2	S => A	1.175↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	2.56x56	186	TM2	S => A	1.0	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	2.60x60	190	TM2	R => A	34.483↓	pK(i) (Binding - Radioligand competition/displacement)	Exendin-4	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	2.60x60	190	TM2	R => A	3.388↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	2.60x60	190	TM2	R => A	20.0↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	2.60x60	190	TM2	R => A	2.188↑	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	3.43x43	240	TM3	N => A	2.137↓	pK(i) (Binding - Radioligand competition/displacement)	Exendin-4	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	3.43x43	240	TM3	N => A	1.514↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	3.43x43	240	TM3	N => A	3.021↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	3.43x43	240	TM3	N => A	1.479↑	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	3.50x50	247	TM3	E => A	2.137↓	pK(i) (Binding - Radioligand competition/displacement)	Exendin-4	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	3.50x50	247	TM3	E => A	1.514↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	3.50x50	247	TM3	E => A	3.021↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	3.50x50	247	TM3	E => A	1.479↑	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	5.50x50	320	TM5	N => A	33.333↓	pK(i) (Binding - Radioligand competition/displacement)	Exendin-4	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	5.50x50	320	TM5	N => A	1.862↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	5.50x50	320	TM5	N => A	17.857↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	5.50x50	320	TM5	N => A	7.937↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	6.42x42	353	TM6	T => A	Abolished effect	pK(i) (Binding - Radioligand competition/displacement)	Exendin-4	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	6.42x42	353	TM6	T => A	Abolished effect	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	6.42x42	353	TM6	T => A	Abolished effect	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	6.42x42	353	TM6	T => A	Abolished effect	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	6.52x52	363	TM6	H => A	27.027↓	pK(i) (Binding - Radioligand competition/displacement)	Exendin-4	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	6.52x52	363	TM6	H => A	5.0↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	6.52x52	363	TM6	H => A	22.727↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	6.52x52	363	TM6	H => A	6.329↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	7.47x46	392	TM7	S => A	1.779↓	pK(i) (Binding - Radioligand competition/displacement)	Exendin-4	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	7.47x46	392	TM7	S => A	2.188↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	7.47x46	392	TM7	S => A	1.779↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	7.47x46	392	TM7	S => A	1.479↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	7.49x49	394	TM7	Q => A	1.779↓	pK(i) (Binding - Radioligand competition/displacement)	Exendin-4	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	7.49x49	394	TM7	Q => A	2.188↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	7.49x49	394	TM7	Q => A	1.779↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	7.49x49	394	TM7	Q => A	1.479↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	7.57x57	402	TM7	Y => A	1.779↓	pK(i) (Binding - Radioligand competition/displacement)	Exendin-4	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	7.57x57	402	TM7	Y => A	2.188↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	7.57x57	402	TM7	Y => A	1.779↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	7.57x57	402	TM7	Y => A	1.479↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	8.47x47	406	H8	N => A	1.779↓	pK(i) (Binding - Radioligand competition/displacement)	Exendin-4	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	8.47x47	406	H8	N => A	2.188↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	8.47x47	406	H8	N => A	1.779↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human	8.47x47	406	H8	N => A	1.479↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2013)	Yang D et al (2016)
glp1r_human		32	N-term	L => A	1.092↑	EC50 (Functional - cAMP accumulation)	Chimer 2	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		32	N-term	L => A	2.0↓	EC50 (Functional - cAMP accumulation)	Chimer 2X	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		32	N-term	L => A	1.499↓	EC50 (Functional - cAMP accumulation)	CHEMBL398714	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		32	N-term	L => A	6.289↓	EC50 (Functional - cAMP accumulation)	exendin-4(1-30)	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		32	N-term	L => A	2.0↓	EC50 (Functional - cAMP accumulation)	exendin-4(1-30)(Gly2Ala)	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		32	N-term	L => A	9.615↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Ala8Gly)	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		32	N-term	L => A	8.621↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Ala8Gly/Gly16Glu/Glu21Leu/Ala24Glu)	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		32	N-term	L => A	2.0↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly16Glu/Glu21Leu/Ala24Glu)	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		32	N-term	L => A	7.143↓	EC50 (Functional - cAMP accumulation)	glucagon-(Ser22Glu)	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		32	N-term	L => A	2.237↓	EC50 (Functional - cAMP accumulation)	glucagon-(Ser22Glu/Gln26Lys)	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		32	N-term	L => A	2.179↓	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		127	N-term	E => A	1.401↓	EC50 (Functional - cAMP accumulation)	CHEMBL398714	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		127	N-term	E => A	1.572↓	EC50 (Functional - cAMP accumulation)	exendin-4(1-30)	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		127	N-term	E => A	1.2↓	EC50 (Functional - cAMP accumulation)	exendin-4(1-30)(Gly2Ala)	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		127	N-term	E => A	1.842↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Ala8Gly)	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		127	N-term	E => A	1.272↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Ala8Gly/Gly16Glu/Glu21Leu/Ala24Glu)	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		127	N-term	E => A	1.143↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly16Glu/Glu21Leu/Ala24Glu)	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		127	N-term	E => A	1.2↓	EC50 (Functional - cAMP accumulation)	glucagon-(Ser22Glu)	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		127	N-term	E => A	1.205↓	EC50 (Functional - cAMP accumulation)	glucagon-(Ser22Glu/Gln26Lys)	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		127	N-term	E => A	1.235↓	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		128	N-term	E => A	1.342↓	EC50 (Functional - cAMP accumulation)	Chimer 2	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		128	N-term	E => A	1.053↓	EC50 (Functional - cAMP accumulation)	Chimer 2	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		128	N-term	E => A	1.105↓	EC50 (Functional - cAMP accumulation)	Chimer 2X	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		128	N-term	E => A	1.027↓	EC50 (Functional - cAMP accumulation)	Chimer 2X	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		128	N-term	E => A	1.901↓	EC50 (Functional - cAMP accumulation)	CHEMBL398714	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		128	N-term	E => A	1.715↓	EC50 (Functional - cAMP accumulation)	exendin-4(1-30)	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		128	N-term	E => A	1.401↓	EC50 (Functional - cAMP accumulation)	exendin-4(1-30)(Gly2Ala)	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		128	N-term	E => A	1.961↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Ala8Gly)	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		128	N-term	E => A	1.546↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Ala8Gly/Gly16Glu/Glu21Leu/Ala24Glu)	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		128	N-term	E => A	1.143↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly16Glu/Glu21Leu/Ala24Glu)	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		128	N-term	E => A	1.017↑	EC50 (Functional - cAMP accumulation)	glucagon-(Ser22Glu)	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		128	N-term	E => A	1.686↓	EC50 (Functional - cAMP accumulation)	glucagon-(Ser22Glu/Gln26Lys)	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human		128	N-term	E => A	1.529↓	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Patterson JT et al (2013)	Graaf Cd et al (2016)
glp1r_human	7.34x33	379	TM7	L => R	1.698↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Asp15Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => R	3.165↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Asp15Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => E	>12.048↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Asp15Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => E	>34.483↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Asp15Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => R	16.129↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Asp15Glu)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => R	142.857↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Asp15Glu)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => E	>34.483↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Asp15Glu)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => E	333.333↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Asp15Glu)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => R	1.382↑	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Asp15Lys)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => R	3.546↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Asp15Lys)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => E	>7.092↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Asp15Lys)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => E	>19.231↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Asp15Lys)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => R	>5.618↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => R	>8.13↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => E	>5.618↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => E	>8.13↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => R	>10.0↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10Asp)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => R	>5.236↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10Asp)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => E	>10.0↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10Asp)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => E	>5.236↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10Asp)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => R	>5.495↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => R	10.0↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => E	>5.495↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => E	>11.765↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => R	>7.752↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10His)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => R	>21.739↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10His)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => E	>7.752↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10His)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => E	>21.739↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10His)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => R	1.0	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10Lys)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => R	1.0	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10Lys)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => E	1.0	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10Lys)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => E	1.0	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10Lys)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => R	11.765↓	IC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => R	142.857↓	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => E	10.753↓	IC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => E	166.667↓	EC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => G	3.609↑	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Asp15Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => G	3.8↑	EC50 (Functional - cAMP accumulation)	GLP-1-(Asp15Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => D	4.368↑	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Asp15Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => D	6.021↑	EC50 (Functional - cAMP accumulation)	GLP-1-(Asp15Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => G	1.074↑	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Asp15Glu)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => G	52.632↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Asp15Glu)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => D	1.414↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Asp15Glu)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => D	333.333↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Asp15Glu)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => G	10.071↑	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Asp15Lys)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => G	2.755↑	EC50 (Functional - cAMP accumulation)	GLP-1-(Asp15Lys)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => D	9.4↑	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Asp15Lys)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => D	4.075↑	EC50 (Functional - cAMP accumulation)	GLP-1-(Asp15Lys)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => G	11.867↑	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => G	7.411↑	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => D	5.086↑	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => D	1.905↑	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => G	>1.923↑	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10Asp)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => G	3.021↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10Asp)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => D	>10.0↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10Asp)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => D	>5.236↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10Asp)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => G	>2.8↑	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => G	7.246↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => D	>5.495↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => D	>11.765↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => G	>2.867↑	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10His)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => G	3.086↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10His)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => D	>7.752↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10His)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => D	>21.739↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10His)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => G	>14.706↑	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10Lys)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => G	1.738↑	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10Lys)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => D	1.0	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10Lys)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => D	1.0	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10Lys)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => G	4.202↓	IC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => G	40.0↓	EC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => D	20.833↓	IC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => D	1000.0↓	EC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => R	1.59↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Asp15Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => E	>12.048↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Asp15Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => R	1.047↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Asp15Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => E	16.129↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Asp15Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => R	1.621↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Asp15Glu)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => E	>34.483↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Asp15Glu)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => R	10.309↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Asp15Glu)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => E	N/A	EC50 (Functional - cAMP accumulation)	GLP-1-(Asp15Glu)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => R	2.39↑	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Asp15Lys)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => E	>7.092↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Asp15Lys)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => R	1.514↑	EC50 (Functional - cAMP accumulation)	GLP-1-(Asp15Lys)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => E	>19.231↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Asp15Lys)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => R	1.202↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => E	>5.618↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => R	1.024↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => E	>8.13↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => R	1.0	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10Asp)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => E	>10.0↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10Asp)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => R	1.585↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10Asp)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => E	>5.236↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10Asp)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => R	1.82↑	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => E	>5.495↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => R	1.024↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => E	>11.765↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10Arg)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => R	1.613↑	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10His)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => E	>7.752↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10His)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => R	1.862↑	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10His)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => E	>21.739↓	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10His)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => R	3.472↑	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10Lys)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => E	1.0	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Gly10Lys)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => R	2.512↑	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10Lys)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => E	1.0	EC50 (Functional - cAMP accumulation)	GLP-1-(Gly10Lys)	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => R	1.2↓	IC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => E	>200.0↓	IC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => R	2.067↑	EC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => E	250.0↓	EC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Moon MJ et al (2015)	Yang D et al (2016)
glp1r_human	4.64x64	288	TM4	K => A	1.412↓	pIC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	4.64x64	288	TM4	K => A	22.727↓	pIC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	4.64x64	288	TM4	K => A	1.486↑	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	4.65x65	289	TM4	Y => A	1.349↑	pIC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	4.65x65	289	TM4	Y => A	1.318↓	pIC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	4.65x65	289	TM4	Y => A	1.096↑	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human		299	ECL2	R => A	1.738↑	pIC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human		299	ECL2	R => A	2.63↑	pIC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human		299	ECL2	R => A	1.084↑	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human		300	ECL2	N => A	1.514↑	pIC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human		300	ECL2	N => A	35.714↓	pIC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human		300	ECL2	N => A	1.211↑	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	5.35x36	305	TM5	Y => A	1.148↓	pIC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	5.35x36	305	TM5	Y => A	1.548↓	pIC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	5.35x36	305	TM5	Y => A	1.064↑	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	5.36x37	306	TM5	W => A	1.82↑	pIC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	5.36x37	306	TM5	W => A	111.111↓	pIC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	5.36x37	306	TM5	W => A	1.251↑	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	5.39x39	309	TM5	I => A	1.096↓	pIC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	5.39x39	309	TM5	I => A	3.311↓	pIC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	5.39x39	309	TM5	I => A	1.116↑	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	5.40x40	310	TM5	R => A	1.047↑	pIC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	5.40x40	310	TM5	R => A	3.472↓	pIC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	5.40x40	310	TM5	R => A	1.369↑	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	6.60x60	371	TM6	M => A	1.23↓	pIC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	6.60x60	371	TM6	M => A	6.329↓	pIC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	6.60x60	371	TM6	M => A	1.046↑	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human		372	ECL3	D => A	1.259↓	pIC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human		372	ECL3	D => A	3.984↓	pIC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human		372	ECL3	D => A	1.179↑	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human		373	ECL3	E => A	1.096↑	pIC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human		373	ECL3	E => A	1.023↑	pIC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human		373	ECL3	E => A	1.02↑	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human		374	ECL3	H => A	1.072↓	pIC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human		374	ECL3	H => A	1.658↓	pIC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human		374	ECL3	H => A	1.004↓	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human		375	ECL3	A => G	4.785↓	pIC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human		375	ECL3	A => G	9.804↓	pIC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human		375	ECL3	A => G	1.082↑	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human		376	ECL3	R => A	1.658↓	pIC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human		376	ECL3	R => A	1.658↓	pIC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human		376	ECL3	R => A	1.005↑	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.32x31	377	TM7	G => A	1.072↓	pIC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.32x31	377	TM7	G => A	2.632↓	pIC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.32x31	377	TM7	G => A	1.034↑	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.33x32	378	TM7	T => A	1.096↓	pIC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.33x32	378	TM7	T => A	1.122↑	pIC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.33x32	378	TM7	T => A	1.017↑	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => A	1.513↓	pIC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => A	2.342↓	pIC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.34x33	379	TM7	L => A	1.027↑	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => A	2.688↓	pIC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => A	125.0↓	pIC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => A	1.264↑	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => A	1.096↓	pIC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => A	1.658↓	pIC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => A	1.018↑	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.37x36	382	TM7	I => A	1.288↑	pIC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.37x36	382	TM7	I => A	2.237↓	pIC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.37x36	382	TM7	I => A	1.026↑	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.38x37	383	TM7	K => A	1.513↓	pIC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.38x37	383	TM7	K => A	3.39↓	pIC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.38x37	383	TM7	K => A	1.177↑	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.39x38	384	TM7	L => A	1.175↑	pIC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.39x38	384	TM7	L => A	6.173↓	pIC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.39x38	384	TM7	L => A	1.053↑	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.40x39	385	TM7	F => A	1.072↓	pIC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.40x39	385	TM7	F => A	3.236↓	pIC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.40x39	385	TM7	F => A	1.004↓	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.41x40	386	TM7	T => A	1.023↑	pIC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.41x40	386	TM7	T => A	3.472↓	pIC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.41x40	386	TM7	T => A	1.019↑	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.42x41	387	TM7	E => A	1.862↓	pIC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.42x41	387	TM7	E => A	2.884↑	pIC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	7.42x41	387	TM7	E => A	1.032↑	EC50 (Functional - cAMP accumulation)	CHEMBL410972	Dods RL et al (2015)	Yang D et al (2016)
glp1r_human	3.43x43	240	TM3	N => Q	1.585↓	pK(i) (Binding - Radioligand competition/displacement)	Exendin-4	Wootten D et al (2016)	Yang D et al (2016)
glp1r_human	3.43x43	240	TM3	N => Q	1.259↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Yang D et al (2016)
glp1r_human	3.43x43	240	TM3	N => Q	1.0	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Yang D et al (2016)
glp1r_human	3.43x43	240	TM3	N => Q	1.995↑	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Yang D et al (2016)
glp1r_human	6.53x53	364	TM6	E => A	31.25↓	pK(i) (Binding - Radioligand competition/displacement)	Exendin-4	Wootten D et al (2016)	Yang D et al (2016)
glp1r_human	6.53x53	364	TM6	E => A	3.984↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Yang D et al (2016)
glp1r_human	6.53x53	364	TM6	E => A	25.0↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Yang D et al (2016)
glp1r_human	6.53x53	364	TM6	E => A	1.585↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Yang D et al (2016)
glp1r_human	7.49x49	394	TM7	Q => N	1.585↓	pK(i) (Binding - Radioligand competition/displacement)	Exendin-4	Wootten D et al (2016)	Yang D et al (2016)
glp1r_human	7.49x49	394	TM7	Q => N	1.259↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Yang D et al (2016)
glp1r_human	7.49x49	394	TM7	Q => N	1.0	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Yang D et al (2016)
glp1r_human	7.49x49	394	TM7	Q => N	1.259↑	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Yang D et al (2016)
glp1r_human	1.36x36	141	TM1	L => A	1.0	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	1.36x36	141	TM1	L => A	3.597↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	1.40x40	145	TM1	Y => A	2.029↑	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	1.40x40	145	TM1	Y => A	1.3↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	1.43x43	148	TM1	Y => F	7.246↓	IC50 (Binding - Radioligand competition/displacement)	Exendin-4	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	1.43x43	148	TM1	Y => F	4.262↑	IC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	1.43x43	148	TM1	Y => F	1.486↑	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	1.43x43	148	TM1	Y => F	11.765↓	IC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	1.43x43	148	TM1	Y => F	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	1.43x43	148	TM1	Y => F	14.493↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	1.43x43	148	TM1	Y => F	9.804↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	1.43x43	148	TM1	Y => A	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	1.43x43	148	TM1	Y => A	25.641↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	1.43x43	148	TM1	Y => N	14.706↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	1.43x43	148	TM1	Y => N	8.0↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	1.43x43	148	TM1	Y => F	1.385↑	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(9-36)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	1.44x44	149	TM1	T => A	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	1.44x44	149	TM1	T => A	58.824↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	1.44x44	149	TM1	T => S	1.449↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	1.44x44	149	TM1	T => S	83.333↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	1.47x47	152	TM1	Y => H	1.816↑	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	1.47x47	152	TM1	Y => H	1.111↑	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.57x57	187	TM2	F => A	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	2.57x57	187	TM2	F => A	Abolished effect	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.60x60	190	TM2	R => K	5.076↓	IC50 (Binding - Radioligand competition/displacement)	Exendin-4	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.60x60	190	TM2	R => K	2.167↑	IC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.60x60	190	TM2	R => K	1.786↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Ala8Ser)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.60x60	190	TM2	R => K	1.44↑	IC50 (Binding - Radioligand competition/displacement)	GLP-1(Glu9Gln)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.60x60	190	TM2	R => K	1.058↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.60x60	190	TM2	R => K	28.571↓	IC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.60x60	190	TM2	R => A	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	2.60x60	190	TM2	R => A	Abolished effect	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.60x60	190	TM2	R => K	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	2.60x60	190	TM2	R => K	16.667↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.60x60	190	TM2	R => K	31.25↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.60x60	190	TM2	R => L	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	2.60x60	190	TM2	R => L	Abolished effect	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.60x60	190	TM2	R => K	1.153↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(9-36)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.62x62	192	TM2	L => S	1.232↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	2.62x62	192	TM2	L => S	3.226↑	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.64x64	194	TM2	V => A	1.319↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	2.64x64	194	TM2	V => A	3.704↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.67x67	197	TM2	K => I	6.494↓	IC50 (Binding - Radioligand competition/displacement)	exendin(15-39)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.67x67	197	TM2	K => I	1.038↓	IC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.67x67	197	TM2	K => I	2.558↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.67x67	197	TM2	K => I	50.0↓	IC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.67x67	197	TM2	K => R	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	2.67x67	197	TM2	K => R	22.727↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.67x67	197	TM2	K => Q	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	2.67x67	197	TM2	K => Q	Abolished effect	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.67x67	197	TM2	K => A	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	2.67x67	197	TM2	K => I	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	2.67x67	197	TM2	K => A	Abolished effect	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.67x67	197	TM2	K => I	Abolished effect	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.67x67	197	TM2	K => I	27.778↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.67x67	197	TM2	K => I	1.667↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(9-36)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.68x68	198	TM2	D => E	11.765↓	IC50 (Binding - Radioligand competition/displacement)	Exendin-4	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.68x68	198	TM2	D => E	1.083↑	IC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.68x68	198	TM2	D => E	2.028↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.68x68	198	TM2	D => E	58.824↓	IC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.68x68	198	TM2	D => A	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	2.68x68	198	TM2	D => A	90.909↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.68x68	198	TM2	D => N	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	2.68x68	198	TM2	D => N	Abolished effect	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.68x68	198	TM2	D => E	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	2.68x68	198	TM2	D => E	500.0↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.68x68	198	TM2	D => E	58.824↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.68x68	198	TM2	D => E	1.519↑	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(9-36)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.71x71	201	TM2	L => A	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	2.71x71	201	TM2	L => A	Abolished effect	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.73x73	203	TM2	W => A	1.595↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	2.73x73	203	TM2	W => A	1.401↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.74x74	204	TM2	M => R	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	2.74x74	204	TM2	M => R	90.909↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.74x74	204	TM2	M => A	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	2.74x74	204	TM2	M => A	333.333↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	2.75x75	205	TM2	Y => A	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	2.75x75	205	TM2	Y => A	62.5↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human		211	ECL1	Q => R	1.014↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human		211	ECL1	Q => R	2.801↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human		211	ECL1	Q => D	1.014↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human		211	ECL1	Q => D	4.608↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human		212	ECL1	H => A	1.754↑	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human		212	ECL1	H => A	1.739↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human		214	ECL1	W => V	2.32↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human		214	ECL1	W => V	3.597↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human		217	ECL1	L => A	1.014↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human		217	ECL1	L => A	2.5↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human		220	ECL1	Y => D	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human		220	ECL1	Y => D	100.0↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	3.36x36	233	TM3	M => A	3.831↓	IC50 (Binding - Radioligand competition/displacement)	Exendin-4	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	3.36x36	233	TM3	M => A	2.364↑	IC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	3.36x36	233	TM3	M => A	1.153↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	3.36x36	233	TM3	M => A	21.739↓	IC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	3.36x36	233	TM3	M => F	1.595↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	3.36x36	233	TM3	M => F	1.499↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	3.36x36	233	TM3	M => A	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	3.36x36	233	TM3	M => A	71.429↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	3.36x36	233	TM3	M => A	15.625↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	3.36x36	233	TM3	M => T	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	3.36x36	233	TM3	M => T	62.5↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	3.36x36	233	TM3	M => A	1.064↑	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(9-36)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	3.37x37	234	TM3	Q => E	3.165↓	IC50 (Binding - Radioligand competition/displacement)	Exendin-4	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	3.37x37	234	TM3	Q => E	4.127↑	IC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	3.37x37	234	TM3	Q => E	1.934↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Ala8Ser)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	3.37x37	234	TM3	Q => E	4.5↑	IC50 (Binding - Radioligand competition/displacement)	GLP-1(Glu9Gln)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	3.37x37	234	TM3	Q => E	1.337↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	3.37x37	234	TM3	Q => E	14.493↓	IC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	3.37x37	234	TM3	Q => N	2.899↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	3.37x37	234	TM3	Q => N	4.695↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	3.37x37	234	TM3	Q => E	16.393↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	3.37x37	234	TM3	Q => E	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	3.37x37	234	TM3	Q => E	29.412↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	3.37x37	234	TM3	Q => A	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	3.37x37	234	TM3	Q => A	142.857↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	3.37x37	234	TM3	Q => E	1.145↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(9-36)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	3.44x44	241	TM3	Y => A	1.045↑	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	3.44x44	241	TM3	Y => A	2.198↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	4.64x64	288	TM4	K => L	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	4.64x64	288	TM4	K => L	Abolished effect	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	4.68x68	292	TM4	E => A	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	4.68x68	292	TM4	E => A	33.333↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	45.50x50	296	ECL2	C => S	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	45.50x50	296	ECL2	C => S	100.0↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	45.51x51	297	ECL2	W => A	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	45.51x51	297	ECL2	W => A	Abolished effect	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	45.51x51	297	ECL2	W => H	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	45.51x51	297	ECL2	W => H	50.0↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human		299	ECL2	R => S	43.478↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human		299	ECL2	R => S	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human		300	ECL2	N => Q	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human		300	ECL2	N => Q	Abolished effect	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	5.34x35	304	TM5	N => A	1.062↑	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	5.34x35	304	TM5	N => A	2.198↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	5.36x37	306	TM5	W => A	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	5.36x37	306	TM5	W => A	Abolished effect	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	6.53x53	364	TM6	E => Q	40.0↑	IC50 (Binding - Radioligand competition/displacement)	exendin(15-39)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	6.53x53	364	TM6	E => Q	40.0↑	IC50 (Binding - Radioligand competition/displacement)	exendin(15-39)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	6.53x53	364	TM6	E => Q	2.0↑	IC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	6.53x53	364	TM6	E => Q	2.0↑	IC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	6.53x53	364	TM6	E => Q	152.5↑	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Ala8Ser)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	6.53x53	364	TM6	E => Q	120.0↑	IC50 (Binding - Radioligand competition/displacement)	GLP-1(Glu9Gln)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	6.53x53	364	TM6	E => Q	4.952↑	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	6.53x53	364	TM6	E => Q	4.952↑	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	6.53x53	364	TM6	E => Q	20.333↑	IC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	6.53x53	364	TM6	E => Q	20.333↑	IC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	6.53x53	364	TM6	E => D	1.449↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	6.53x53	364	TM6	E => D	1.695↑	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	6.53x53	364	TM6	E => Q	50.0↑	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	6.53x53	364	TM6	E => Y	1.739↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	6.53x53	364	TM6	E => Y	1.1↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	6.53x53	364	TM6	E => Q	3.136↑	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	6.53x53	364	TM6	E => Q	1.149↑	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	6.53x53	364	TM6	E => Q	50.0↑	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	6.53x53	364	TM6	E => A	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	6.53x53	364	TM6	E => A	Abolished effect	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	6.53x53	364	TM6	E => Q	10.636↑	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(9-36)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	6.53x53	364	TM6	E => Q	10.636↑	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(9-36)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	6.56x56	367	TM6	F => A	10.87↓	IC50 (Binding - Radioligand competition/displacement)	exendin(15-39)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	6.56x56	367	TM6	F => A	2.653↓	IC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	6.56x56	367	TM6	F => A	4.975↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	6.56x56	367	TM6	F => A	71.429↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	6.56x56	367	TM6	F => A	35.714↓	IC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	6.56x56	367	TM6	F => A	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	6.56x56	367	TM6	F => A	32.258↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	6.56x56	367	TM6	F => H	7.692↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	6.56x56	367	TM6	F => H	125.0↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	6.56x56	367	TM6	F => I	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	6.56x56	367	TM6	F => I	19.608↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	6.56x56	367	TM6	F => A	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(9-36)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human		374	ECL3	H => A	1.327↑	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human		374	ECL3	H => A	1.401↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human		376	ECL3	R => Q	1.095↑	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human		376	ECL3	R => Q	2.801↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	7.35x34	380	TM7	R => Q	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	7.35x34	380	TM7	R => Q	Abolished effect	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	7.36x35	381	TM7	F => S	2.174↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	7.36x35	381	TM7	F => S	2.398↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	7.39x38	384	TM7	L => A	5.0↓	IC50 (Binding - Radioligand competition/displacement)	exendin(15-39)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	7.39x38	384	TM7	L => A	3.25↑	IC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	7.39x38	384	TM7	L => A	1.072↑	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	7.39x38	384	TM7	L => A	31.25↓	IC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	7.39x38	384	TM7	L => V	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	7.39x38	384	TM7	L => V	16.393↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	7.39x38	384	TM7	L => A	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	7.39x38	384	TM7	L => A	40.0↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	7.39x38	384	TM7	L => A	47.619↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	7.39x38	384	TM7	L => A	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(9-36)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	7.42x41	387	TM7	E => D	3.584↓	IC50 (Binding - Radioligand competition/displacement)	exendin(15-39)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	7.42x41	387	TM7	E => D	1.13↑	IC50 (Binding - Radioligand competition/displacement)	exendin-(9-39)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	7.42x41	387	TM7	E => D	2.652↑	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(Ala8Ser)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	7.42x41	387	TM7	E => D	2.558↓	IC50 (Binding - Radioligand competition/displacement)	GLP-1(Glu9Gln)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	7.42x41	387	TM7	E => D	1.284↑	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	7.42x41	387	TM7	E => D	9.804↓	IC50 (Binding - Radioligand competition/displacement)	CHEMBL410972	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	7.42x41	387	TM7	E => D	13.699↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	7.42x41	387	TM7	E => D	10.417↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	7.42x41	387	TM7	E => D	11.905↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	7.42x41	387	TM7	E => N	1.42↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	7.42x41	387	TM7	E => N	2.083↑	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	7.42x41	387	TM7	E => D	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	GLP-1-(9-36)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	7.43x42	388	TM7	L => F	1.348↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	7.43x42	388	TM7	L => F	4.0↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	7.43x42	388	TM7	L => A	Abolished effect	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	7.43x42	388	TM7	L => A	200.0↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human	7.43x42	388	TM7	L => I	5.076↓	IC50 (Binding - Radioligand competition/displacement)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Yang D et al (2016)
glp1r_human	7.43x42	388	TM7	L => I	83.333↓	EC50 (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Yang D et al (2016)	Graaf Cd et al (2016)
glp1r_human		67	N-term	D => R	Abolished effect	Single-point (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Zhao LH et al (2016)	Salam W et al (2025)
glp1r_human		90	N-term	P => R	Abolished effect	Single-point (Functional - cAMP accumulation)	glucagon-like peptide 1-(7-37)	Zhao LH et al (2016)	Salam W et al (2025)
glp1r_human	2.71x71	201	TM2	L => A	14.085↓	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.71x71	201	TM2	L => A	1.905↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.71x71	201	TM2	L => A	333.333↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.71x71	201	TM2	L => A	15.152↓	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.71x71	201	TM2	L => A	1.996↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.71x71	201	TM2	L => A	5.128↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.71x71	201	TM2	L => A	15.385↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.71x71	201	TM2	L => A	9.091↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.71x71	201	TM2	L => A	Abolished effect	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.71x71	201	TM2	L => A	8.333↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.71x71	201	TM2	L => A	18.519↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.71x71	201	TM2	L => A	1.585↓	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.72x72	202	TM2	K => A	52.632↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.72x72	202	TM2	K => A	4.464↓	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.72x72	202	TM2	K => A	1.698↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.72x72	202	TM2	K => A	15.152↓	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.72x72	202	TM2	K => A	2.342↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.72x72	202	TM2	K => A	1.024↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.72x72	202	TM2	K => A	18.519↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.72x72	202	TM2	K => A	2.188↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.72x72	202	TM2	K => A	8.929↓	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.72x72	202	TM2	K => A	3.636↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.72x72	202	TM2	K => A	7.752↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.72x72	202	TM2	K => A	3.236↑	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.73x73	203	TM2	W => A	1.289↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.73x73	203	TM2	W => A	1.047↓	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.73x73	203	TM2	W => A	1.122↓	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.73x73	203	TM2	W => A	1000.0↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.73x73	203	TM2	W => A	1.175↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.73x73	203	TM2	W => A	3.39↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.73x73	203	TM2	W => A	1.739↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.73x73	203	TM2	W => A	3.472↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.73x73	203	TM2	W => A	3.165↓	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.73x73	203	TM2	W => A	1.445↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.73x73	203	TM2	W => A	1.288↑	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.73x73	203	TM2	W => A	15.136↑	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.74x74	204	TM2	M => A	5.495↓	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.74x74	204	TM2	M => A	13.514↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.74x74	204	TM2	M => A	1000.0↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.74x74	204	TM2	M => A	Abolished effect	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.74x74	204	TM2	M => A	1.513↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.74x74	204	TM2	M => A	52.632↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.74x74	204	TM2	M => A	47.619↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.74x74	204	TM2	M => A	22.222↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.74x74	204	TM2	M => A	Abolished effect	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.74x74	204	TM2	M => A	13.158↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.74x74	204	TM2	M => A	28.571↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.74x74	204	TM2	M => A	1.122↓	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.75x75	205	TM2	Y => A	8.547↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.75x75	205	TM2	Y => A	13.514↓	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.75x75	205	TM2	Y => A	1000.0↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.75x75	205	TM2	Y => A	12.658↓	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.75x75	205	TM2	Y => A	1.148↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.75x75	205	TM2	Y => A	3.236↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.75x75	205	TM2	Y => A	2.882↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.75x75	205	TM2	Y => A	5.747↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.75x75	205	TM2	Y => A	3.546↓	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.75x75	205	TM2	Y => A	2.137↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.75x75	205	TM2	Y => A	6.329↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.75x75	205	TM2	Y => A	1.862↑	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.76x76	206	TM2	S => A	2.455↑	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.76x76	206	TM2	S => A	1.905↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.76x76	206	TM2	S => A	2.042↑	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.76x76	206	TM2	S => A	333.333↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.76x76	206	TM2	S => A	1.445↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.76x76	206	TM2	S => A	1.318↑	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.76x76	206	TM2	S => A	1.318↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.76x76	206	TM2	S => A	1.288↑	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.76x76	206	TM2	S => A	2.088↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.76x76	206	TM2	S => A	1.259↑	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.76x76	206	TM2	S => A	1.349↑	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	2.76x76	206	TM2	S => A	15.849↑	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		207	ECL1	T => A	1.289↓	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		207	ECL1	T => A	1.818↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		207	ECL1	T => A	166.667↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		207	ECL1	T => A	1.949↓	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		207	ECL1	T => A	1.175↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		207	ECL1	T => A	3.636↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		207	ECL1	T => A	1.23↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		207	ECL1	T => A	3.021↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		207	ECL1	T => A	1.0	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		207	ECL1	T => A	6.024↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		207	ECL1	T => A	1.024↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		207	ECL1	T => A	1.95↑	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		210	ECL1	Q => A	2.138↑	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		210	ECL1	Q => A	1.996↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		210	ECL1	Q => A	1.445↓	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		210	ECL1	Q => A	166.667↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		210	ECL1	Q => A	1.072↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		210	ECL1	Q => A	1.548↓	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		210	ECL1	Q => A	2.399↑	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		210	ECL1	Q => A	1.072↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		210	ECL1	Q => A	1.318↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		210	ECL1	Q => A	3.39↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		210	ECL1	Q => A	4.367↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		210	ECL1	Q => A	3.467↑	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		211	ECL1	Q => A	1.318↑	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		211	ECL1	Q => A	2.398↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		211	ECL1	Q => A	1.148↑	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		211	ECL1	Q => A	200.0↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		211	ECL1	Q => A	1.23↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		211	ECL1	Q => A	1.047↑	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		211	ECL1	Q => A	4.167↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		211	ECL1	Q => A	1.259↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		211	ECL1	Q => A	3.311↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		211	ECL1	Q => A	1.072↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		211	ECL1	Q => A	3.165↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		211	ECL1	Q => A	3.715↑	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		212	ECL1	H => A	71.429↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		212	ECL1	H => A	2.089↑	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		212	ECL1	H => A	1.0	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		212	ECL1	H => A	1.995↑	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		212	ECL1	H => A	1.0	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		212	ECL1	H => A	1.148↑	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		212	ECL1	H => A	2.288↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		212	ECL1	H => A	1.122↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		212	ECL1	H => A	1.096↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		212	ECL1	H => A	1.514↑	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		212	ECL1	H => A	1.148↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		212	ECL1	H => A	10.233↑	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		213	ECL1	Q => A	2.457↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		213	ECL1	Q => A	1.175↓	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		213	ECL1	Q => A	1.289↓	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		213	ECL1	Q => A	333.333↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		213	ECL1	Q => A	1.0	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		213	ECL1	Q => A	1.318↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		213	ECL1	Q => A	1.739↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		213	ECL1	Q => A	2.632↓	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		213	ECL1	Q => A	3.472↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		213	ECL1	Q => A	1.0	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		213	ECL1	Q => A	1.202↑	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		213	ECL1	Q => A	11.749↑	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		214	ECL1	W => A	250.0↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		214	ECL1	W => A	1.445↓	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		214	ECL1	W => A	1.621↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		214	ECL1	W => A	1.818↓	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		214	ECL1	W => A	1.513↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		214	ECL1	W => A	5.128↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		214	ECL1	W => A	3.636↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		214	ECL1	W => A	10.204↓	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		214	ECL1	W => A	5.128↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		214	ECL1	W => A	1.658↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		214	ECL1	W => A	2.882↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		214	ECL1	W => A	4.074↑	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		215	ECL1	D => A	1.38↑	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		215	ECL1	D => A	2.688↓	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		215	ECL1	D => A	62.5↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		215	ECL1	D => A	1.548↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		215	ECL1	D => A	1.148↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		215	ECL1	D => A	1.047↑	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		215	ECL1	D => A	3.802↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		215	ECL1	D => A	1.479↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		215	ECL1	D => A	2.632↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		215	ECL1	D => A	1.996↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		215	ECL1	D => A	1.445↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		215	ECL1	D => A	5.888↑	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		217	ECL1	L => A	1.585↓	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		217	ECL1	L => A	2.632↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		217	ECL1	L => A	1.549↑	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		217	ECL1	L => A	250.0↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		217	ECL1	L => A	1.122↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		217	ECL1	L => A	1.096↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		217	ECL1	L => A	9.091↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		217	ECL1	L => A	1.289↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		217	ECL1	L => A	2.571↓	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		217	ECL1	L => A	1.548↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		217	ECL1	L => A	1.096↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		217	ECL1	L => A	10.715↑	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		218	ECL1	L => A	8.696↓	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		218	ECL1	L => A	9.346↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		218	ECL1	L => A	1.996↓	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		218	ECL1	L => A	333.333↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		218	ECL1	L => A	2.088↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		218	ECL1	L => A	5.495↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		218	ECL1	L => A	6.024↓	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		218	ECL1	L => A	7.092↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		218	ECL1	L => A	4.367↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		218	ECL1	L => A	12.821↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		218	ECL1	L => A	3.236↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		218	ECL1	L => A	1.096↓	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		219	ECL1	S => A	1.658↓	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		219	ECL1	S => A	1.148↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		219	ECL1	S => A	47.619↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		219	ECL1	S => A	2.089↑	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		219	ECL1	S => A	1.862↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		219	ECL1	S => A	1.259↑	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		219	ECL1	S => A	1.148↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		219	ECL1	S => A	2.138↑	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		219	ECL1	S => A	1.259↑	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		219	ECL1	S => A	1.349↑	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		219	ECL1	S => A	1.412↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		219	ECL1	S => A	8.318↑	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		220	ECL1	Y => A	1.202↑	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		220	ECL1	Y => A	200.0↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		220	ECL1	Y => A	1.318↑	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		220	ECL1	Y => A	3.802↓	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		220	ECL1	Y => A	1.202↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		220	ECL1	Y => A	1.202↓	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		220	ECL1	Y => A	1.548↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		220	ECL1	Y => A	1.862↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		220	ECL1	Y => A	1.585↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		220	ECL1	Y => A	4.464↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		220	ECL1	Y => A	2.137↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		220	ECL1	Y => A	2.63↑	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		221	ECL1	Q => A	5.0↓	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		221	ECL1	Q => A	1.585↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		221	ECL1	Q => A	1.047↑	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		221	ECL1	Q => A	200.0↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		221	ECL1	Q => A	1.862↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		221	ECL1	Q => A	1.549↑	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		221	ECL1	Q => A	1.698↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		221	ECL1	Q => A	2.237↓	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		221	ECL1	Q => A	1.548↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		221	ECL1	Q => A	1.413↑	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		221	ECL1	Q => A	2.041↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		221	ECL1	Q => A	5.754↑	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		222	ECL1	D => A	142.857↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		222	ECL1	D => A	1.905↑	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		222	ECL1	D => A	1.445↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		222	ECL1	D => A	1.23↓	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		222	ECL1	D => A	1.072↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		222	ECL1	D => A	1.585↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		222	ECL1	D => A	1.381↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		222	ECL1	D => A	1.905↑	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		222	ECL1	D => A	1.072↑	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		222	ECL1	D => A	2.041↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		222	ECL1	D => A	1.658↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		222	ECL1	D => A	7.079↑	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		223	ECL1	S => A	3.891↓	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		223	ECL1	S => A	66.667↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		223	ECL1	S => A	2.688↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		223	ECL1	S => A	1.122↑	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		223	ECL1	S => A	1.288↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		223	ECL1	S => A	1.862↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		223	ECL1	S => A	1.996↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		223	ECL1	S => A	2.755↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		223	ECL1	S => A	2.288↓	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		223	ECL1	S => A	3.802↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		223	ECL1	S => A	2.188↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		223	ECL1	S => A	3.09↑	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		372	ECL3	D => A	31.25↓	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		372	ECL3	D => A	12.658↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		372	ECL3	D => A	500.0↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		372	ECL3	D => A	15.873↓	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		372	ECL3	D => A	3.891↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		372	ECL3	D => A	66.667↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		372	ECL3	D => A	40.0↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		372	ECL3	D => A	142.857↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		372	ECL3	D => A	10.989↓	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		372	ECL3	D => A	3.086↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		372	ECL3	D => A	62.5↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		372	ECL3	D => A	8.696↓	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		373	ECL3	E => A	18.519↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		373	ECL3	E => A	62.5↓	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		373	ECL3	E => A	N/A	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		373	ECL3	E => A	Abolished effect	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		373	ECL3	E => A	1.175↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		373	ECL3	E => A	47.619↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		373	ECL3	E => A	1000.0↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		373	ECL3	E => A	31.25↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		373	ECL3	E => A	Abolished effect	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		373	ECL3	E => A	7.407↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		373	ECL3	E => A	32.258↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		373	ECL3	E => A	4.464↓	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		374	ECL3	H => A	1.259↑	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		374	ECL3	H => A	1.024↓	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		374	ECL3	H => A	1.318↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		374	ECL3	H => A	38.462↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		374	ECL3	H => A	7.407↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		374	ECL3	H => A	1.288↑	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		374	ECL3	H => A	1.513↓	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		374	ECL3	H => A	2.188↑	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		374	ECL3	H => A	1.445↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		374	ECL3	H => A	1.148↑	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		374	ECL3	H => A	1.658↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		374	ECL3	H => A	8.318↑	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		376	ECL3	R => A	1.585↓	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		376	ECL3	R => A	1.047↑	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		376	ECL3	R => A	2.088↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		376	ECL3	R => A	200.0↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		376	ECL3	R => A	2.688↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		376	ECL3	R => A	1.023↑	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		376	ECL3	R => A	2.632↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		376	ECL3	R => A	3.984↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		376	ECL3	R => A	1.548↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		376	ECL3	R => A	1.445↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		376	ECL3	R => A	1.381↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human		376	ECL3	R => A	5.248↑	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.32x31	377	TM7	G => A	2.688↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.32x31	377	TM7	G => A	66.667↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.32x31	377	TM7	G => A	1.259↓	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.32x31	377	TM7	G => A	1.122↓	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.32x31	377	TM7	G => A	1.096↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.32x31	377	TM7	G => A	3.546↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.32x31	377	TM7	G => A	7.937↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.32x31	377	TM7	G => A	2.513↓	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.32x31	377	TM7	G => A	3.021↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.32x31	377	TM7	G => A	2.571↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.32x31	377	TM7	G => A	2.188↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.32x31	377	TM7	G => A	3.311↑	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.33x32	378	TM7	T => A	3.236↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.33x32	378	TM7	T => A	3.631↑	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.33x32	378	TM7	T => A	35.714↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.33x32	378	TM7	T => A	2.512↑	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.33x32	378	TM7	T => A	1.318↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.33x32	378	TM7	T => A	3.548↑	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.33x32	378	TM7	T => A	1.096↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.33x32	378	TM7	T => A	3.09↑	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.33x32	378	TM7	T => A	3.981↑	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.33x32	378	TM7	T => A	4.274↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.33x32	378	TM7	T => A	1.023↑	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.33x32	378	TM7	T => A	7.413↑	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.34x33	379	TM7	L => A	5.618↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.34x33	379	TM7	L => A	1000.0↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.34x33	379	TM7	L => A	3.984↓	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.34x33	379	TM7	L => A	23.81↓	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.34x33	379	TM7	L => A	1.202↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.34x33	379	TM7	L => A	47.619↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.34x33	379	TM7	L => A	58.824↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.34x33	379	TM7	L => A	2.571↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.34x33	379	TM7	L => A	Abolished effect	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.34x33	379	TM7	L => A	7.092↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.34x33	379	TM7	L => A	30.303↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.34x33	379	TM7	L => A	4.167↓	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.35x34	380	TM7	R => A	29.412↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.35x34	380	TM7	R => A	200.0↓	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.35x34	380	TM7	R => A	N/A	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.35x34	380	TM7	R => A	Abolished effect	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.35x34	380	TM7	R => A	1.548↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.35x34	380	TM7	R => A	1000.0↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.35x34	380	TM7	R => A	12.658↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.35x34	380	TM7	R => A	13.514↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.35x34	380	TM7	R => A	Abolished effect	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.35x34	380	TM7	R => A	3.891↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.35x34	380	TM7	R => A	Abolished effect	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.35x34	380	TM7	R => A	Abolished effect	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.36x35	381	TM7	F => A	125.0↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.36x35	381	TM7	F => A	2.571↓	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.36x35	381	TM7	F => A	1.779↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.36x35	381	TM7	F => A	1.259↓	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.36x35	381	TM7	F => A	22.727↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.36x35	381	TM7	F => A	5.012↑	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.36x35	381	TM7	F => A	2.137↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.36x35	381	TM7	F => A	5.128↓	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.36x35	381	TM7	F => A	1.949↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.36x35	381	TM7	F => A	13.158↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.36x35	381	TM7	F => A	2.95↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.36x35	381	TM7	F => A	2.455↑	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.37x36	382	TM7	I => A	125.0↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.37x36	382	TM7	I => A	1.318↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.37x36	382	TM7	I => A	2.513↓	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.37x36	382	TM7	I => A	1.445↓	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.37x36	382	TM7	I => A	1.096↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.37x36	382	TM7	I => A	2.692↑	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.37x36	382	TM7	I => A	1.175↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.37x36	382	TM7	I => A	2.817↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.37x36	382	TM7	I => A	4.566↓	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.37x36	382	TM7	I => A	1.175↑	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.37x36	382	TM7	I => A	2.571↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.37x36	382	TM7	I => A	2.818↑	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.38x37	383	TM7	K => A	11.236↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.38x37	383	TM7	K => A	76.923↓	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.38x37	383	TM7	K => A	Abolished effect	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.38x37	383	TM7	K => A	Abolished effect	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.38x37	383	TM7	K => A	8.547↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.38x37	383	TM7	K => A	1000.0↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.38x37	383	TM7	K => A	9.804↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.38x37	383	TM7	K => A	40.0↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.38x37	383	TM7	K => A	Abolished effect	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.38x37	383	TM7	K => A	7.937↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.38x37	383	TM7	K => A	16.129↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.38x37	383	TM7	K => A	2.237↓	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.39x38	384	TM7	L => A	500.0↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.39x38	384	TM7	L => A	3.984↓	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.39x38	384	TM7	L => A	12.658↓	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.39x38	384	TM7	L => A	14.493↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.39x38	384	TM7	L => A	2.137↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.39x38	384	TM7	L => A	16.667↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.39x38	384	TM7	L => A	22.222↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.39x38	384	TM7	L => A	2.513↓	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.39x38	384	TM7	L => A	11.494↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.39x38	384	TM7	L => A	12.346↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.39x38	384	TM7	L => A	6.757↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.39x38	384	TM7	L => A	1.698↓	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.40x39	385	TM7	F => A	1.658↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.40x39	385	TM7	F => A	1.349↑	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.40x39	385	TM7	F => A	142.857↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.40x39	385	TM7	F => A	1.996↓	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.40x39	385	TM7	F => A	1.175↑	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.40x39	385	TM7	F => A	1.66↑	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.40x39	385	TM7	F => A	2.188↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.40x39	385	TM7	F => A	3.891↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.40x39	385	TM7	F => A	1.148↓	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.40x39	385	TM7	F => A	1.35↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.40x39	385	TM7	F => A	3.891↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.40x39	385	TM7	F => A	1.862↑	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.41x40	386	TM7	T => A	3.636↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.41x40	386	TM7	T => A	1.259↑	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.41x40	386	TM7	T => A	200.0↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.41x40	386	TM7	T => A	5.0↓	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.41x40	386	TM7	T => A	1.0	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.41x40	386	TM7	T => A	2.188↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.41x40	386	TM7	T => A	1.0	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.41x40	386	TM7	T => A	1.23↓	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.41x40	386	TM7	T => A	3.311↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.41x40	386	TM7	T => A	1.175↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.41x40	386	TM7	T => A	1.349↑	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.41x40	386	TM7	T => A	9.772↑	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.42x41	387	TM7	E => A	1.349↑	pEC50 (Functional - Ca2+ accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.42x41	387	TM7	E => A	1.996↓	pEC50 (Functional - cAMP accumulation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.42x41	387	TM7	E => A	2.457↓	pK(i) (Binding - Radioligand competition/displacement)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.42x41	387	TM7	E => A	333.333↓	pEC50 (Functional - ERK activation)	exendin(15-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.42x41	387	TM7	E => A	1.548↓	pK(i) (Binding - Radioligand competition/displacement)	exendin-(9-39)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.42x41	387	TM7	E => A	1.259↓	pEC50 (Functional - cAMP accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.42x41	387	TM7	E => A	1.585↓	pK(i) (Binding - Radioligand competition/displacement)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.42x41	387	TM7	E => A	1.513↓	pEC50 (Functional - Ca2+ accumulation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.42x41	387	TM7	E => A	3.086↓	pEC50 (Functional - ERK activation)	CHEMBL410972	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.42x41	387	TM7	E => A	2.755↓	pK(i) (Binding - Radioligand competition/displacement)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.42x41	387	TM7	E => A	15.873↓	pEC50 (Functional - cAMP accumulation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
glp1r_human	7.42x41	387	TM7	E => A	2.188↓	pEC50 (Functional - ERK activation)	Oxyntomodulin(30-37)	Wootten D et al (2016)	Salam W et al (2025)
Protein name	Generic number	Segment	Position	Mutation	FoldChange or Qual	Exp Type	Ligand	Reference	Review

Residue

Diagrams

Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

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Residue Table

GPCRdb(A)	GPCRdb(B)	GLP-1 receptor
TM1
1x32	1.36x36	L141
1x36	1.40x40	Y145
1x39	1.43x43	Y148
1x40	1.44x44	T149
1x43	1.47x47	Y152
1x46	1.50x50	S155
TM2
2x43	2.50x50	H180
2x49	2.56x56	S186
2x50	2.57x57	F187
2x53	2.60x60	R190
2x55	2.62x62	L192
2x57	2.64x64	V194
2x58	2.65x65	F195
2x60	2.67x67	K197
2x61	2.68x68	D198
2x64	2.71x71	L201
2x65	2.72x72	K202
2x66	2.73x73	W203
2x67	2.74x74	M204
2x68	2.75x75	Y205
2x69	2.76x76	S206
TM3
3x32	3.36x36	M233
3x33	3.37x37	Q234
3x34	3.38x38	Y235
3x39	3.43x43	N240
3x40	3.44x44	Y241
3x46	3.50x50	E247
TM4
4x54	4.54x54	L278
4x60	4.60x60	W284
4x61	4.61x61	G285
4x62	4.62x62	I286
4x63	4.63x63	V287
4x64	4.64x64	K288
4x65	4.65x65	Y289
4x66	4.66x66	L290
4x67	4.67x67	Y291
4x68	4.68x68	E292
TM5
5x37	5.32x33	N302
5x38	5.33x34	M303
5x39	5.34x35	N304
5x40	5.35x36	Y305
5x41	5.36x37	W306
5x42	5.37x38	L307
5x43	5.39x39	I309
5x44	5.40x40	R310
5x54	5.50x50	N320
TM6
6x37	6.42x42	T353
6x47	6.52x52	H363
6x48	6.53x53	E364
6x51	6.56x56	F367
6x55	6.60x60	M371
TM7
7x27	7.32x31	G377
7x28	7.33x32	T378
7x29	7.34x33	L379
7x30	7.35x34	R380
7x31	7.36x35	F381
7x32	7.37x36	I382
7x33	7.38x37	K383
7x34	7.39x38	L384
7x35	7.40x39	F385
7x36	7.41x40	T386
7x37	7.42x41	E387
7x38	7.43x42	L388
7x41	7.46x45	T391
7x42	7.47x46	S392
7x45	7.49x49	Q394
7x48	7.52x52	M397
7x53	7.57x57	Y402
H8
8x47	8.47x47	N406

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