Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
gp143_human 5 N-term R => C N/A N/A d'Addio M et al (2000)
gp143_human 1.41x41 35 TM1 G => D N/A N/A d'Addio M et al (2000)
gp143_human 2.50x50 78 TM2 D => N N/A N/A d'Addio M et al (2000)
gp143_human 2.56x56 84 TM2 G => D N/A N/A d'Addio M et al (2000)
gp143_human 3.25x25 116 TM3 C => S N/A N/A d'Addio M et al (2000)
gp143_human 3.27x27 118 TM3 G => E N/A N/A d'Addio M et al (2000)
gp143_human 3.33x33 124 TM3 Q => R N/A N/A d'Addio M et al (2000)
gp143_human 3.42x42 133 TM3 W => R N/A N/A d'Addio M et al (2000)
gp143_human 3.47x47 138 TM3 A => V N/A N/A d'Addio M et al (2000)
gp143_human 152 ICL2 S => N N/A N/A d'Addio M et al (2000)
gp143_human 4.61x61 173 TM4 A => D N/A N/A d'Addio M et al (2000)
gp143_human 229 ICL3 G => V N/A N/A d'Addio M et al (2000)
gp143_human 232 ICL3 T => K N/A N/A d'Addio M et al (2000)
gp143_human 6.22x22 235 TM6 E => K N/A N/A d'Addio M et al (2000)
gp143_human 6.31x31 244 TM6 I => V N/A N/A d'Addio M et al (2000)
gp143_human 6.48x48 261 TM6 I => N N/A N/A d'Addio M et al (2000)
gp143_human 6.58x58 271 TM6 E => G N/A N/A d'Addio M et al (2000)
gp143_human 7.35x34 292 TM7 W => G N/A N/A d'Addio M et al (2000)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 P G R R P A G P G S P A T S P P ICL1ECL1 P N F V D S V S D M N H T E ECL1ICL2 A G L S ICL2ECL2 P S V S R C E R ECL2ICL3 Q G I Y T ICL3ECL3 T D I N G G S ECL3N-term M A S P R L G T F C C P T R D A A T Q L V L S F N-termC-term G W T G C S L G F Q S P R K E I Q W E S L T T S A A E G A H P S P L M P H E N P A S G K V S Q V G G Q T S D E A L S M L S E G S D A S T I E I H T A S E S C N K N E G D P A L P T H G D L C-term Q P R A F H A L C L G S G G L R L A L G L L Q L L A S V R I L R A A A A C D L L G C L G M V I R S T V W L G F I W P A A F C V G S A M W I Q L L Y S A C F W W L F C Y A V D A Y L V I R R S T I L L Y H I M A W G L A T L L C V E G A A M L Y Y G L D H A I P H Y V T M Y L P L L L V L V A N P I L F Q K T V T A V A S L L K G R E N E R R M G A V I K I R F F K I M L V L I I C W L S N I I N E S L L F Y L E M Q L K P V R T A A K T T W F I M G I L N P A Q G F L L S L A F Y
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
L G L A L R L G G S G L C L A H F A R P 1 R A A A A C D L L G C L G M V I R S T V 2 C F L W W F C A S Y L L Q I W M A S G V 3 I L L Y H I M A W G L A T L L C V E G A 4 F L I P N A V L V L L L P L Y M T V Y H 5 L V L I I C W L S N I I N E S L L F Y L 6 L S L L F G Q A P N L I G M I F W T T 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
GPR143
TM1
1x41 1.41x41 G35
TM2
2x50 2.50x50 D78
2x56 2.56x56 G84
TM3
3x25 3.25x25 C116
3x27 3.27x27 G118
3x33 3.33x33 Q124
3x42 3.42x42 W133
3x47 3.47x47 A138
TM4
4x61 4.61x61 A173
TM6
6x22 6.22x22 E235
6x31 6.31x31 I244
6x48 6.48x48 I261
6x58 6.58x58 E271
TM7
7x34 7.35x34 W292