Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
hrh2_human 8.51x51 296 H8 R => C N/A N/A Meletiadis J et al (2006)
hrh2_human 3.32x32 98 TM3 D => N Abolished effect K(d) (Binding - Radioligand competition/displacement) tiotidine Gantz I et al (1992) Kooistra AJ et al (2013)
hrh2_human 5.42x43 186 TM5 D => A Abolished effect K(d) (Binding - Radioligand competition/displacement) tiotidine Gantz I et al (1992) Kooistra AJ et al (2013)
hrh2_human 5.46x461 190 TM5 T => A 23.81↓ K(d) (Binding - Radioligand competition/displacement) tiotidine Gantz I et al (1992) Kooistra AJ et al (2013)
hrh2_human 5.46x461 190 TM5 T => C 21.739↓ K(d) (Binding - Radioligand competition/displacement) tiotidine Gantz I et al (1992) Kooistra AJ et al (2013)
hrh2_human 5.46x461 190 TM5 T => A 5.988↓ IC50 (Binding - Radioligand competition/displacement) cimetidine Gantz I et al (1992) Kooistra AJ et al (2013)
hrh2_human 5.46x461 190 TM5 T => C 8.0↓ IC50 (Binding - Radioligand competition/displacement) cimetidine Gantz I et al (1992) Kooistra AJ et al (2013)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 R R L R ICL1ECL1 K W S F ECL1ICL2 P L R Y P V L V ICL2ECL2 W N S R N E T S K G N H T T S K C K V Q V ECL2ICL3 H I S ICL3ECL3 G D D A I ECL3N-term M A P N G T A S S N-termC-term C R L A N R N S H K T S L R S N A S Q L S R T Q S R E P R Q Q E E K P L K L Q V W S G T E V T A P Q G A T D R C-term F C L D S T A C K I T I T V V L A V L I L I T V A G N V V V C L A V G L N N L T N C F I V S L A I T D L L L G L L V L P F S A I Y Q L S C G K V F C N I Y T S L D V M L C T A S I L N L F M I S L D R Y C A V M D T P V R V A I S L V L I W V I S I T L S F L S I H L G N E V Y G L V D G L V T F Y L P L L I M C I T Y Y R I F K V A R D Q A K R I N S W K A A T I R E H K A T V T L A A V M G A F I I C W F P Y F T A F V Y R G L R N E V L E A I V L W L G Y A N S A L N P I L Y A A L N R D Y Q Q F R T G L F C
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
V N G A V T I L I L V A L V V T I T I K 1 V S L A I T D L L L G L L V L P F S A I Y 2 M F L N L I S A T C L M V D L S T Y I N 3 V A I S L V L I W V I S I T L S F L S I 4 Y T I C M I L L P L Y F T V L G D V L G Y 5 A A V M G A F I I C W F P Y F T A F V Y 6 I P N L A S N A Y G L W L V I A E L V 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
H2 receptor
TM3
3x32 3.32x32 D98
TM5
5x43 5.42x43 D186
5x461 5.46x461 T190
H8
8x51 8.51x51 R296