Mutant Browser

Download
Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
pi2r_human 328 C-term S => A N/A N/A Smyth EM et al (1998)
pi2r_human 374 C-term S => A N/A N/A Smyth EM et al (1998)
pi2r_human 328 C-term S => A N/A N/A Smyth EM et al (2000)
pi2r_human 374 C-term S => A N/A N/A Smyth EM et al (2000)
pi2r_human 5 N-term C => A N/A N/A Stitham J et al (2002)
pi2r_human 7 N-term N => P N/A N/A Stitham J et al (2003)
pi2r_human 1.36x36 17 TM1 P => A N/A N/A Stitham J et al (2002)
pi2r_human 1.39x39 20 TM1 S => A N/A N/A Stitham J et al (2003)
pi2r_human 1.43x43 24 TM1 F => A N/A N/A Stitham J et al (2003)
pi2r_human 1.44x44 25 TM1 V => M N/A N/A Stitham J et al (2002)
pi2r_human 1.44x44 25 TM1 V => M N/A N/A Stitham J et al (2003)
pi2r_human 42 ICL1 R => G N/A N/A Zhang L et al (2005)
pi2r_human 43 ICL1 P => G N/A N/A Zhang L et al (2005)
pi2r_human 44 ICL1 A => G N/A N/A Zhang L et al (2005)
pi2r_human 45 ICL1 R => E N/A N/A Zhang L et al (2005)
pi2r_human 45 ICL1 R => K N/A N/A Zhang L et al (2005)
pi2r_human 45 ICL1 R => L N/A N/A Zhang L et al (2005)
pi2r_human 45 ICL1 R => Q N/A N/A Zhang L et al (2005)
pi2r_human 45 ICL1 R => T N/A N/A Zhang L et al (2005)
pi2r_human 46 ICL1 P => A N/A N/A Zhang L et al (2005)
pi2r_human 46 ICL1 P => G N/A N/A Zhang L et al (2005)
pi2r_human 2.37x37 47 TM2 S => A N/A N/A Zhang L et al (2005)
pi2r_human 2.37x37 47 TM2 S => G N/A N/A Zhang L et al (2005)
pi2r_human 2.37x37 47 TM2 S => L N/A N/A Zhang L et al (2005)
pi2r_human 2.37x37 47 TM2 S => T N/A N/A Zhang L et al (2005)
pi2r_human 2.38x38 48 TM2 A => G N/A N/A Zhang L et al (2005)
pi2r_human 2.38x38 48 TM2 A => L N/A N/A Zhang L et al (2005)
pi2r_human 2.38x38 48 TM2 A => T N/A N/A Zhang L et al (2005)
pi2r_human 2.38x38 48 TM2 A => V N/A N/A Zhang L et al (2005)
pi2r_human 2.50x50 60 TM2 D => A N/A N/A Stitham J et al (2003)
pi2r_human 2.55x55 65 TM2 S => A N/A N/A Stitham J et al (2003)
pi2r_human 2.56x56 66 TM2 F => A N/A N/A Stitham J et al (2003)
pi2r_human 2.57x57 67 TM2 L => A N/A N/A Stitham J et al (2003)
pi2r_human 2.57x57 67 TM2 L => W N/A N/A Stitham J et al (2003)
pi2r_human 2.58x58 68 TM2 S => A N/A N/A Stitham J et al (2003)
pi2r_human 2.59x59 69 TM2 P => A N/A N/A Stitham J et al (2002)
pi2r_human 2.61x61 71 TM2 V => F N/A N/A Stitham J et al (2003)
pi2r_human 2.61x61 71 TM2 V => L N/A N/A Stitham J et al (2003)
pi2r_human 2.62x62 72 TM2 F => A N/A N/A Stitham J et al (2003)
pi2r_human 2.65x65 75 TM2 Y => A N/A N/A Stitham J et al (2003)
pi2r_human 2.65x65 75 TM2 Y => F N/A N/A Stitham J et al (2003)
pi2r_human 2.65x65 75 TM2 Y => S N/A N/A Stitham J et al (2003)
pi2r_human 2.68x68 78 TM2 N => P N/A N/A Stitham J et al (2003)
pi2r_human 3.22x22 89 TM3 P => A N/A N/A Stitham J et al (2002)
pi2r_human 3.26x26 93 TM3 D => A N/A N/A Stitham J et al (2003)
pi2r_human 3.28x28 95 TM3 F => A N/A N/A Stitham J et al (2003)
pi2r_human 3.30x30 97 TM3 F => A N/A N/A Stitham J et al (2003)
pi2r_human 3.32x32 99 TM3 M => L N/A N/A Stitham J et al (2003)
pi2r_human 3.33x33 100 TM3 T => A N/A N/A Stitham J et al (2003)
pi2r_human 3.34x34 101 TM3 F => A N/A N/A Stitham J et al (2003)
pi2r_human 3.35x35 102 TM3 F => A N/A N/A Stitham J et al (2003)
pi2r_human 3.39x39 106 TM3 S => A N/A N/A Stitham J et al (2003)
pi2r_human 4.47x47 141 TM4 P => A N/A N/A Stitham J et al (2002)
pi2r_human 4.56x56 150 TM4 F => A N/A N/A Stitham J et al (2003)
pi2r_human 4.60x60 154 TM4 P => A N/A N/A Stitham J et al (2002)
pi2r_human 5.32x32 179 TM5 P => A N/A N/A Stitham J et al (2002)
pi2r_human 5.37x37 184 TM5 F => A N/A N/A Stitham J et al (2003)
pi2r_human 5.38x38 185 TM5 S => A N/A N/A Stitham J et al (2003)
pi2r_human 5.41x41 188 TM5 Y => A N/A N/A Stitham J et al (2003)
pi2r_human 5.65x65 212 TM5 R => H N/A N/A Stitham J et al (2002)
pi2r_human 5.65x65 212 TM5 R => H N/A N/A Stitham J et al (2003)
pi2r_human 6.48x48 252 TM6 S => A N/A N/A Stitham J et al (2003)
pi2r_human 6.50x50 254 TM6 P => A N/A N/A Stitham J et al (2002)
pi2r_human 6.54x54 258 TM6 R => A N/A N/A Stitham J et al (2003)
pi2r_human 6.56x56 260 TM6 F => A N/A N/A Stitham J et al (2003)
pi2r_human 271 ECL3 E => A N/A N/A Stitham J et al (2003)
pi2r_human 7.35x34 274 TM7 D => A N/A N/A Stitham J et al (2003)
pi2r_human 7.39x38 278 TM7 F => A N/A N/A Stitham J et al (2003)
pi2r_human 7.40x39 279 TM7 R => A N/A N/A Stitham J et al (2003)
pi2r_human 7.41x40 280 TM7 F => A N/A N/A Stitham J et al (2003)
pi2r_human 7.42x41 281 TM7 Y => A N/A N/A Stitham J et al (2003)
pi2r_human 7.44x43 283 TM7 F => A N/A N/A Stitham J et al (2003)
pi2r_human 7.46x46 285 TM7 P => A N/A N/A Stitham J et al (2002)
pi2r_human 7.50x50 289 TM7 P => A N/A N/A Stitham J et al (2002)
pi2r_human 8.59x59 308 H8 C => S N/A N/A Miggin SM et al (2003)
pi2r_human 8.60x60 309 H8 C => S N/A N/A Miggin SM et al (2003)
pi2r_human 8.62x62 311 H8 C => S N/A N/A Miggin SM et al (2003)
pi2r_human 328 C-term S => A N/A N/A Smyth EM et al (2000)
pi2r_human 328 C-term S => A N/A N/A Miggin SM et al (2002)
pi2r_human 328 C-term S => A N/A N/A Smyth EM et al (1998)
pi2r_human 374 C-term S => A N/A N/A Smyth EM et al (2000)
pi2r_human 374 C-term S => A N/A N/A Smyth EM et al (1998)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 R P A R P ICL1ECL1 S S L L G L A R G G ECL1ICL2 P Y L Y A Q L D ICL2ECL2 L G Q H Q Q Y C P G S W C F L R M R W A ECL2ICL3 G S L G P R P R T G E ICL3ECL3 P D S S S E M G ECL3N-term M A D S C R N L T Y V R G S V G N-termC-term P A H G D S Q T P L S Q L A S G R R D P R A P S A P V G K E G S C V P L S A W G E G Q V E P L P P T Q Q S S G S A V G T S S K A E A S V A C S L C C-term P A T S T L M F V A G V V G N G L A L G I L S A R S A F A V L V T G L A A T D L L G T S F L S P A V F V A Y A R N P A L C D A F A F A M T F F G L A S M L I L F A M A V E R C L A L S H G P R C A R L A L P A I Y A F C V L F C A L P L L G Q P G G A A F S L A Y A G L V A L L V A A I F L C N G S V T L S L C R M Y R Q Q K R H Q D E V D H L I L L A L M T V V M A V C S L P L T I R C F T Q A V A D L L A F R F Y A F N P I L D P W V F I L F R K A L K L L C L V F Q R W V C C G
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
G N G V V G A V F M L T S T A P 1 T G L A A T D L L G T S F L S P A V F V 2 A F L I L M S A L G F F T M A F A F A D 3 A R L A L P A I Y A F C V L F C A L P L 4 S G N C L F I A A V L L A V L G A Y A L 5 A L M T V V M A V C S L P L T I R C F T 6 W P D L I P N F A Y F R F A L L D 7
Download: PNG | SVG




Residue Table


GPCRdb(A)
GPCRdb(A)
IP receptor
TM1
1x36 1.36x36 P17
1x39 1.39x39 S20
1x43 1.43x43 F24
1x44 1.44x44 V25
TM2
2x37 2.37x37 S47
2x38 2.38x38 A48
2x50 2.50x50 D60
2x55 2.55x55 S65
2x56 2.56x56 F66
2x57 2.57x57 L67
2x58 2.58x58 S68
2x59 2.59x59 P69
2x61 2.61x61 V71
2x62 2.62x62 F72
2x65 2.65x65 Y75
2x68 2.68x68 N78
TM3
3x22 3.22x22 P89
3x26 3.26x26 D93
3x28 3.28x28 F95
3x30 3.30x30 F97
3x32 3.32x32 M99
3x33 3.33x33 T100
3x34 3.34x34 F101
3x35 3.35x35 F102
3x39 3.39x39 S106
TM4
4x47 4.47x47 P141
4x56 4.56x56 F150
4x60 4.60x60 P154
TM5
5x32 5.32x32 P179
5x37 5.37x37 F184
5x38 5.38x38 S185
5x41 5.41x41 Y188
5x65 5.65x65 R212
TM6
6x48 6.48x48 S252
6x50 6.50x50 P254
6x54 6.54x54 R258
6x56 6.56x56 F260
TM7
7x34 7.35x34 D274
7x38 7.39x38 F278
7x39 7.40x39 R279
7x40 7.41x40 F280
7x41 7.42x41 Y281
7x43 7.44x43 F283
7x46 7.46x46 P285
7x50 7.50x50 P289
H8
8x59 8.59x59 C308
8x60 8.60x60 C309
8x62 8.62x62 C311