Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
ednrb_human 2.53x53 150 TM2 H => A N/A N/A Lee JA et al (1994)
ednrb_human 2.53x53 150 TM2 H => Y N/A N/A Lee JA et al (1994)
ednrb_human 3.25x25 174 TM3 C => A N/A N/A Haendler B et al (1993)
ednrb_human 45.50x50 255 ECL2 C => A N/A N/A Haendler B et al (1993)
ednrb_human 7.25x24 358 TM7 C => A N/A N/A Haendler B et al (1993)
ednrb_human 2.57x56 154 TM2 D => A N/A N/A Rose PM et al (1995)
ednrb_human 2.50x50 147 TM2 D => A N/A N/A Rose PM et al (1995)
ednrb_human 2.53x53 150 TM2 H => A N/A N/A Rose PM et al (1995)
ednrb_human 2.53x53 150 TM2 H => Y N/A N/A Rose PM et al (1995)
ednrb_human 5.41x42 276 TM5 W => C N/A N/A Puffenberger EG et al (1994)
ednrb_human 3.26x26 175 TM3 K => R N/A N/A Lee JA et al (1994)
ednrb_human 3.26x26 175 TM3 K => A N/A N/A Lee JA et al (1994)
ednrb_human 3.33x33 182 TM3 K => M N/A N/A Lee JA et al (1994)
ednrb_human 3.33x33 182 TM3 K => R N/A N/A Lee JA et al (1994)
ednrb_human 3.33x33 182 TM3 K => A N/A N/A Lee JA et al (1994)
ednrb_human 3.33x33 182 TM3 K => D N/A N/A Lee JA et al (1994)
ednrb_human 3.33x33 182 TM3 K => E N/A N/A Lee JA et al (1994)
ednrb_human 3.25x25 174 TM3 C => A N/A N/A Haendler B et al (1993)
ednrb_human 45.50x50 255 ECL2 C => A N/A N/A Haendler B et al (1993)
ednrb_human 241 ECL2 D => V N/A N/A Sakamoto A et al (1993)
ednrb_human 6.59x59 347 TM6 L => K N/A N/A Sakamoto A et al (1993)
ednrb_human 2.64x63 161 TM2 K => I N/A N/A Adachi M et al (1994)
ednrb_human 8.59x59 402 H8 C => S N/A N/A Okamoto Y et al (1998)
ednrb_human 8.60x60 403 H8 C => S N/A N/A Okamoto Y et al (1998)
ednrb_human 405 C-term C => S N/A N/A Okamoto Y et al (1998)
ednrb_human 16 N-term V => A N/A N/A Charron P et al (2001)
ednrb_human 57 N-term G => S N/A N/A Abe Y et al (2000)
ednrb_human 57 N-term G => S N/A N/A Fuchs S et al (2001)
ednrb_human 57 N-term G => S N/A N/A Amiel J et al (1996)
ednrb_human 57 N-term G => S N/A N/A Svensson PJ et al (1998)
ednrb_human 57 N-term G => S N/A N/A Soufir N et al (2005)
ednrb_human 1.35x35 104 TM1 N => I N/A N/A Abe Y et al (2000)
ednrb_human 1.35x35 104 TM1 N => I N/A N/A Tanoue A et al (2002)
ednrb_human 1.35x35 104 TM1 N => I N/A N/A Tanaka H et al (1998)
ednrb_human 1.40x40 109 TM1 C => R N/A N/A Imamura F et al (2000)
ednrb_human 1.40x40 109 TM1 C => R N/A N/A Abe Y et al (2000)
ednrb_human 1.40x40 109 TM1 C => R N/A N/A Tanoue A et al (2002)
ednrb_human 1.40x40 109 TM1 C => R N/A N/A Tanaka H et al (1998)
ednrb_human 3.36x36 185 TM3 V => M N/A N/A Garcia-Barcelo M et al (2004)
ednrb_human 3.47x47 196 TM3 S => N N/A N/A Sangkhathat S et al (2005)
ednrb_human 3.52x52 201 TM3 R => X N/A N/A Verheij JB et al (2002)
ednrb_human 246 ECL2 D => F N/A N/A Soufir N et al (2005)
ednrb_human 260 ECL2 V => F N/A N/A Soufir N et al (2005)
ednrb_human 5.40x41 275 TM5 W => A N/A N/A Imamura F et al (2000)
ednrb_human 5.40x41 275 TM5 W => F N/A N/A Imamura F et al (2000)
ednrb_human 5.41x42 276 TM5 W => A N/A N/A Imamura F et al (2000)
ednrb_human 5.41x42 276 TM5 W => C N/A N/A Imamura F et al (2000)
ednrb_human 5.41x42 276 TM5 W => C N/A N/A Abe Y et al (2000)
ednrb_human 5.41x42 276 TM5 W => C N/A N/A Tanoue A et al (2002)
ednrb_human 5.41x42 276 TM5 W => C N/A N/A Puffenberger EG et al (1994)
ednrb_human 5.41x42 276 TM5 W => C N/A N/A Auricchio A et al (1996)
ednrb_human 5.41x42 276 TM5 W => C N/A N/A Amiel J et al (1996)
ednrb_human 5.41x42 276 TM5 W => C N/A N/A Soufir N et al (2005)
ednrb_human 5.41x42 276 TM5 W => F N/A N/A Imamura F et al (2000)
ednrb_human 5.50x50 285 TM5 P => L N/A N/A Abe Y et al (2000)
ednrb_human 5.58x58 293 TM5 Y => L N/A N/A Imamura F et al (2000)
ednrb_human 5.58x58 293 TM5 Y => L N/A N/A Abe Y et al (2000)
ednrb_human 5.70x70 305 TM5 S => N N/A N/A Brooks AS et al (1999)
ednrb_human 5.70x70 305 TM5 S => N N/A N/A Abe Y et al (2000)
ednrb_human 5.70x70 305 TM5 S => N N/A N/A Auricchio A et al (1996)
ednrb_human 5.70x70 305 TM5 S => N N/A N/A Soufir N et al (2005)
ednrb_human 6.31x31 319 TM6 R => W N/A N/A Abe Y et al (2000)
ednrb_human 6.31x31 319 TM6 R => W N/A N/A Fuchs S et al (2001)
ednrb_human 6.31x31 319 TM6 R => W N/A N/A Amiel J et al (1996)
ednrb_human 7.41x40 374 TM7 M => I N/A N/A Abe Y et al (2000)
ednrb_human 7.45x45 378 TM7 N => I N/A N/A Imamura F et al (2000)
ednrb_human 7.45x45 378 TM7 N => I N/A N/A Auricchio A et al (1996)
ednrb_human 7.50x50 383 TM7 P => L N/A N/A Abe Y et al (2000)
ednrb_human 7.50x50 383 TM7 P => L N/A N/A Fuchs S et al (2001)
ednrb_human 7.50x50 383 TM7 P => L N/A N/A Garcia-Barcelo M et al (2004)
ednrb_human 7.50x50 383 TM7 P => L N/A N/A Amiel J et al (1996)
ednrb_human 8.47x47 390 H8 S => R N/A N/A Imamura F et al (2000)
ednrb_human 8.47x47 390 H8 S => R N/A N/A Abe Y et al (2000)
ednrb_human 8.47x47 390 H8 S => R N/A N/A Tanoue A et al (2002)
ednrb_human 8.47x47 390 H8 S => R N/A N/A Tanaka H et al (1998)
ednrb_human 434 C-term R => C N/A N/A Soufir N et al (2005)
ednrb_human 2.64x63 161 TM2 K => A 3.333↓ IC50 (Binding - Radioligand competition/displacement) endothelin-1 Shihoya W et al (2016)
ednrb_human 3.32x32 181 TM3 Q => A 2.0↓ IC50 (Binding - Radioligand competition/displacement) endothelin-1 Shihoya W et al (2016)
ednrb_human 3.33x33 182 TM3 K => A 6.993↓ IC50 (Binding - Radioligand competition/displacement) endothelin-1 Shihoya W et al (2016)
ednrb_human 247 ECL2 Y => A 4.329↓ IC50 (Binding - Radioligand competition/displacement) endothelin-1 Shihoya W et al (2016)
ednrb_human 5.35x36 270 TM5 K => A 3.333↓ IC50 (Binding - Radioligand competition/displacement) endothelin-1 Shihoya W et al (2016)
ednrb_human 5.38x39 273 TM5 K => A 5.682↓ IC50 (Binding - Radioligand competition/displacement) endothelin-1 Shihoya W et al (2016)
ednrb_human 5.42x43 277 TM5 L => A 6.993↓ IC50 (Binding - Radioligand competition/displacement) endothelin-1 Shihoya W et al (2016)
ednrb_human 6.48x48 336 TM6 W => A 4.673↓ IC50 (Binding - Radioligand competition/displacement) endothelin-1 Shihoya W et al (2016)
ednrb_human 6.51x51 339 TM6 L => A 9.709↓ IC50 (Binding - Radioligand competition/displacement) endothelin-1 Shihoya W et al (2016)
ednrb_human 6.55x55 343 TM6 R => A 3.003↓ IC50 (Binding - Radioligand competition/displacement) endothelin-1 Shihoya W et al (2016)
ednrb_human 6.62x62 350 TM6 Y => A 3.003↓ IC50 (Binding - Radioligand competition/displacement) endothelin-1 Shihoya W et al (2016)
ednrb_human 7.24x23 357 TM7 R => A 5.988↓ IC50 (Binding - Radioligand competition/displacement) endothelin-1 Shihoya W et al (2016)
ednrb_human 7.31x30 364 TM7 L => A 2.331↓ IC50 (Binding - Radioligand competition/displacement) endothelin-1 Shihoya W et al (2016)
ednrb_human 7.32x31 365 TM7 L => A 6.993↓ IC50 (Binding - Radioligand competition/displacement) endothelin-1 Shihoya W et al (2016)
ednrb_human 7.35x34 368 TM7 D => A 5.348↓ IC50 (Binding - Radioligand competition/displacement) endothelin-1 Shihoya W et al (2016)
ednrb_human 7.36x35 369 TM7 Y => A 3.333↓ IC50 (Binding - Radioligand competition/displacement) endothelin-1 Shihoya W et al (2016)
ednrb_human 2.64x63 161 TM2 K => A 166.667↓ IC50 (Binding - Radioligand competition/displacement) endothelin-3 Shihoya W et al (2016)
ednrb_human 3.32x32 181 TM3 Q => A 9.009↓ IC50 (Binding - Radioligand competition/displacement) endothelin-3 Shihoya W et al (2016)
ednrb_human 3.33x33 182 TM3 K => A 333.333↓ IC50 (Binding - Radioligand competition/displacement) endothelin-3 Shihoya W et al (2016)
ednrb_human 247 ECL2 Y => A 10.989↓ IC50 (Binding - Radioligand competition/displacement) endothelin-3 Shihoya W et al (2016)
ednrb_human 5.35x36 270 TM5 K => A 3.663↓ IC50 (Binding - Radioligand competition/displacement) endothelin-3 Shihoya W et al (2016)
ednrb_human 5.38x39 273 TM5 K => A 200.0↓ IC50 (Binding - Radioligand competition/displacement) endothelin-3 Shihoya W et al (2016)
ednrb_human 5.42x43 277 TM5 L => A 14.085↓ IC50 (Binding - Radioligand competition/displacement) endothelin-3 Shihoya W et al (2016)
ednrb_human 6.48x48 336 TM6 W => A 5.988↓ IC50 (Binding - Radioligand competition/displacement) endothelin-3 Shihoya W et al (2016)
ednrb_human 6.51x51 339 TM6 L => A 25.641↓ IC50 (Binding - Radioligand competition/displacement) endothelin-3 Shihoya W et al (2016)
ednrb_human 6.55x55 343 TM6 R => A 4.0↓ IC50 (Binding - Radioligand competition/displacement) endothelin-3 Shihoya W et al (2016)
ednrb_human 6.62x62 350 TM6 Y => A 40.0↓ IC50 (Binding - Radioligand competition/displacement) endothelin-3 Shihoya W et al (2016)
ednrb_human 7.24x23 357 TM7 R => A 250.0↓ IC50 (Binding - Radioligand competition/displacement) endothelin-3 Shihoya W et al (2016)
ednrb_human 7.31x30 364 TM7 L => A 5.0↓ IC50 (Binding - Radioligand competition/displacement) endothelin-3 Shihoya W et al (2016)
ednrb_human 7.32x31 365 TM7 L => A 27.778↓ IC50 (Binding - Radioligand competition/displacement) endothelin-3 Shihoya W et al (2016)
ednrb_human 7.35x34 368 TM7 D => A 5.348↓ IC50 (Binding - Radioligand competition/displacement) endothelin-3 Shihoya W et al (2016)
ednrb_human 7.36x35 369 TM7 Y => A 15.385↓ IC50 (Binding - Radioligand competition/displacement) endothelin-3 Shihoya W et al (2016)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 K C M R N ICL1ECL1 E D W P F ECL1ICL2 W S R I K G I G ICL2ECL2 D I I T M D Y K G S Y L R I C L L H P V Q K ECL2ICL3 Q I A L ICL3ECL3 N Q N D P N ECL3N-term M Q P P P S L C G R A L V A L V L A C G L S R I W G E E R G F P P D R A T P L L Q T A E I M T P P T K T L W P K G S N A S L A R S L A P A E V P K G D R T A G S P P R T I S P P P C N-termC-term W C Q S F E E K Q S L E E K Q S C L K F K A N D H G Y D N F R S S N K Y S S S C-term Q G P I E I K E T F K Y I N T V V S C L V F V L G I I G N S T L L R I I Y K N G P N I L I A S L A L G D L L H I V I D I P I N V Y K L L A G A E M C K L V P F I Q K A S V G I T V L S L C A L S I D R Y R A V A S V P K W T A V E I V L I W V V S V V L A V P E A I G F T A F M Q F Y K T A K D W W L F S F Y F C L P L A I T A F F Y T L M T C E M L R K K S G M N D H L K Q R R E V A K T V F C L V L V F A L C W L P L H L S R I L K L T L Y R C E L L S F L L V L D Y I G I N M A S L N S C I N P I A L Y L V S K R F K S F K N C C L C C
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
S N G I I G L V F V L C S V V T N I Y K 1 A S L A L G D L L H I I V D I P I N V Y K 2 A C L S L V T I G V S A K Q I F P V L K 3 T A V E I V L I W V V S V V L A V P E 4 Y F F A T I A L P L C F Y F S F L W W D K 5 F C L V L V F A L C W L P L H L S R I L 6 I P N I C S N L S A M N I G I Y D L V 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
ETB receptor
TM1
1x35 1.35x35 N104
1x40 1.40x40 C109
TM2
2x50 2.50x50 D147
2x53 2.53x53 H150
2x56 2.57x56 D154
2x63 2.64x63 K161
TM3
3x25 3.25x25 C174
3x26 3.26x26 K175
3x32 3.32x32 Q181
3x33 3.33x33 K182
3x36 3.36x36 V185
3x47 3.47x47 S196
3x52 3.52x52 R201
TM5
5x36 5.35x36 K270
5x39 5.38x39 K273
5x41 5.40x41 W275
5x42 5.41x42 W276
5x43 5.42x43 L277
5x50 5.50x50 P285
5x58 5.58x58 Y293
5x70 5.70x70 S305
TM6
6x31 6.31x31 R319
6x48 6.48x48 W336
6x51 6.51x51 L339
6x55 6.55x55 R343
6x59 6.59x59 L347
6x62 6.62x62 Y350
TM7
7x23 7.24x23 R357
7x24 7.25x24 C358
7x30 7.31x30 L364
7x31 7.32x31 L365
7x34 7.35x34 D368
7x35 7.36x35 Y369
7x40 7.41x40 M374
7x45 7.45x45 N378
7x50 7.50x50 P383
H8
8x47 8.47x47 S390
8x59 8.59x59 C402
8x60 8.60x60 C403